Capitalbio Corporation

Sichuan University

Capitalbio Technology Corporation

Tsinghua University

Juan Xin

Lei Wang

Jing Cheng

Xinying Zhou

Li Li Ma

Mingxian Lin

Can Wang

Yao Zhang

Wanli Xing

Xiang Chen

Su Li

Guoliang Huang

Liang Bai

Libing Dong

Yanan Wang

Tengfei Guo

Guohao Zhang

Baolian Li

Longtang Zheng

Fei Wen

Li Ma

Wentian Zhang

Jinhai Feng

A nucleic acid extraction composition, reagents and kits containing the same and uses thereof. Provided is a nucleic acid extraction and purification reagent free of volatile organic solvents, which prevents the damage of volatile organic solvents to people and greatly improves the timeliness of nucleic acid extraction and purification, making the operation extremely simple, and the nucleic acid can be obtained within 10 minutes. The obtained nucleic acid may be used for biological reactions such as PCR, NASBA, LAMP and RPA. Moreover, the reagents of the present disclosure may be used to extract nucleic acids of cells, bacteria, fungi, DNA viruses and RNA viruses from various samples such as blood, throat swab preserving fluid, saliva, urine, sputum, excrement and the like, and very suitable for clinical and scientific research uses.

Nucleic acid extraction composition, reagent and kit containing the same and use thereof

A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.

Valve system for driving fluid and method for using the same

A multi-index detection microfluidic chip is provided. A bottom plate () and a cover plate () that matches the bottom plate () and seals it are provided in the microfluidic chip. The center of the microfluidic chip has a through-hole (). The bottom plate () has one or more wave-shaped main channel(s) (), one end of each of the main channel () connected to a sample injection hole () on the bottom plate (), and the other end connected to an exhaust hole () on the bottom plate (). The valley on the main channel () is distal to the through-hole (), and the peak is proximal to the through-hole (). Each valley of the main channel () is connected to a reaction chamber () by a linking channel (). The linking channel () comprises one or more buffering chambers (). The microfluidic chip can be used in detection by fluorescence, turbidity, color, detection equipment, and/or direct observation by the naked eyes. The detection is real-time as the reaction occurs or after the reaction.

Multi-index detection microfluidic chip and methods of use

In one aspect, disclosed herein are methods for packaging biochips, including microfluidic chips. The method can comprise bonding a substrate and a cover slide, packaging the bonded chip, creating a vacuum in the package, and applying a pressure on the packaged chip. The method is particularly useful for minimizing bubble formation during low-cost and mass production of microfluidic chips.

Method for manufacturing and/or packaging a chip

Growing community of inventors

Beijing, China

Juan Xin