Evonik Roehm Gmbh

Evonik Rohm Gmbh

Juan Tome Alcalde

Norbert Windhab

Benedikt Hartwig

Christian Meier

Rosario Lizio

Michael Damm

Michael Gottschalk

Andreas Gryczke

Melanie Liefke

Maria Del Pilar Ansuategui Panzano

Matias Javier Vara Carrera

Angela Olf

María Del Pilar Ansuategui Panzano

Matías Javier Vara Carrera

The invention refers to a human lactoferrin derived peptide for use as an antigen masking agent in the production of a pharmaceutical composition for delivery of a biological active substance in a mammalian organism, where the biological active substance is able to induce an undesired immune response by the mammalian organism, where the pharmaceutical composition comprises a supramolecular aggregate of the biological active substance and the human lactoferrin derived peptide, with the effect that after delivery of pharmaceutical composition to the mammalian organism, there is no or only a diminished induction of the undesired immune response against the biological active substance.

Human lactoferrin derived peptide for use as an antigen masking agent

The invention relates to an oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles, wherein the dosage form has an at least two phase composition, wherein the phases can dissolve in the body after oral administration due to their formulation and the magnetizable particles are bound in formulation auxiliary substances and are present in a magnetized state, wherein the magnetized particles are present in at least two phases of the dosage form and generate magnetic fields, wherein these phases dissolve at different times in the body after oral administration, and wherein the magnetic field strength with respect to time, position and movement in the body is acquired using a detection system and can be evaluated using a computer-based evaluation system.

Oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles

Growing community of inventors

Madrid, Spain

Juan Tome Alcalde