Shanxi Zhendong Pilot Biological Science and Technology Co., Ltd.

Other

East China University of Science and Technology

The Second Military Medical University

Juan Su

Weidong Zhang

Runhui Liu

Huiliang Li

Xike Xu

Lei Shan

Huizi Jin

Yunheng Shen

Jin Huang

Honglin Li

Tong Chen

Chuan Yu Zhang

Hanxiong Li

Liyan Wang

Shoude Zhang

Weiqiang Lu

Preparation and application of line leafflower lactone A for treating myocarditis having a structure of The compound shows positive therapeutic activity against Coxsackie virus and significant dose dependent correlation. The line leafflower lactone A prevents disease in mouse models of experimental autoimmune myocarditis and onset of the process by intraperitoneal injection of a dose of 20 mg/kg/d. When increased to 100 mg/kg/d, the line leafflower lactone A shows positive therapeutic effect on EAM. Line leafflower lactone A is used as the sole active ingredient and combined with a conventional pharmaceutical carrier in a drug for treating myocarditis, and the pharmaceutical composition may be in the form of tablets, dispersible tablets, mouth collapse tablets, retard tablets, capsule, soft capsule, dropping pill, granules, injection, powder injection, or aerosol.

Line leaf inula flower lactone A and methods for preparing and using the same for treating myocarditis

Preparation and application of line leafflower lactone A in the multiple sclerosis, having a structure of  Line leafflower lactone A has therapeutic effects on experimental autoimmune encephalomyelitis (EAE) model, and is used to develop drug for treating multiple sclerosis (MS). Line leafflower lactone A drug is a combination containing the active ingredient of line leafflower lactone A and conventional pharmaceutically carrier, and may be in forms of tablets, dispersible tablets, mouth collapse tablets, retard tablets, capsule, soft capsule, dropping pill, granules, injection, powder injection, or aerosol. The pharmaceutical composition is used for treating multiple sclerosis, has tremendous developing potentiality because of its high value of clinical application.

Line leaf inula flower lactone A and methods for preparing and using the same for treating multiple sclerosis

A method for treatment of malaria including administering to a patient in need thereof a flavonoid glycoside compound.

Method for treatment of malaria

A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant 'Yan Huang Lian' (Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal composition containing them

Growing community of inventors

Shanghai, China

Juan Su