Shire Human Genetic Therapies, Inc.

Instrumentation Laboratory S.p.a.

Juan Ruiz

Marcia Sellos-Moura

Michael F Concino

Paolo Martini

Bettina Strack-Logue

Cheryl Brucato

Pau Bruguera

Cynthia Birr

Pan Luying

Demetrio Sanchez-Martinez

Scott Alderucci

Philip Shi

Luying Pan

Described herein are isolated nucleic acid molecules comprising nucleotide sequence encoding mannose receptor, C type 1 (MRC1) wherein the 5' region of the nucleotide sequence encoding MRC1 is codon optimized; cells comprising such nucleic acid molecules; and methods of detecting antibody production, e.g., neutralizing antibody production, in a subject being treated for Gaucher disease using such cells.

Mannose receptor C type 1 (MRC1) codon optimized cell line and uses thereof

Disclosed herein are novel methods, assays and kits useful for the diagnosis and monitoring of subjects with mucopolysaccharidoses (MPS), The methods, assays and kits are particularly useful for detecting the presence of one or more glycosaminoglycans which correlate to MPS and its severity in a variety of biological samples.

Assays for detection of glycosaminoglycans

Liquid and lyophilized reagents for determining prothrombin time and/or fibrinogen levels in a plasma sample are disclosed. The reagents preferably are based on recombinant rabbit tissue factor. Also disclosed is a purified preparation of recombinant rabbit tissue factor having unique properties, and a novel method for making PT reagents.

Recombinant rabbit tissue factor based prothrombin time reagent

Growing community of inventors

Acton, MA, United States of America

Juan Ruiz