Fundacion Para La Investigacion Medica Aplicada

Proyecto De Biomedicina Cima, S.l.

Juan Roberto Rodríguez Madoz

Julen Oyarzabal Santamarina

Maria Obdulia Rabal Gracia

Felipe Prósper Cardoso

Edurne San José Enériz

Jesús Prieto Valtueña

Xabier Aguirre Ena

Erkuden Casales Zoco

Nerea Razquín Erro

Yolanda Cuevas Labrador

Marta Ruiz Guillén

Cristian Smerdou Picazo

It relates to the use of compounds of formula (I'), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, as anticancer agents and as agents for generating induced pluripotent stem cells. Compounds of formula (I&#x2032;), wherein R&#x2032; is an alcoxy group, a hydrocarbon chain or a ring system, and R, R, and Rare as defined herein, are dual inhibitors of histone methyltransferases and DNA methyltransferases. It also relates to the compounds of formula (I&#x2032;), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein R&#x2032; is phenyl or 5- to 6-membered heteroaromatic ring, both optionally fused to another rings (i.e., compounds of formula (I)). It also relates to pharmaceutical or veterinary compositions containing compounds of formula (I). 

Compounds as dual inhibitors of histone methyltransferases and DNA methyltransferases

Growing community of inventors

Pamplona, Spain

Juan Roberto Rodríguez Madoz