Lacer, S.a.

Juan Martinez Bonnin

Francisco Pubill Coy

Jose Repolles Moliner

Lydia Cabeza Llorente

Eduardo Salas Perez-Rasilla

Alicia Ferrer Siso

Marcelli Carbo Banus

Cristina Negrie Rofes

Marek W Radomski

Juan Antonio Cerda Riudavets

Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I)in which A and B independently represent any of the groups&#x2014;ONOand &#x2014;Z&#x2014;CO&#x2014;R, wherein Z is an oxygen atom or sulphur atom and R is an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, or the groupin which Ris hydrogen, or an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, with the proviso that one of A or B is always &#x2014;ONO, but never both of them at the same time, when Z is an sulphur atom R is an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, and when Z is an oxygen atom R is the group

Derivatives of isosorbide mononitrate and its use as vasodilating agents with reduced tolerance

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Barcelona, Spain

Juan Martinez Bonnin