Leland Stanford Junior University

California Institute of Technology

Other

Juan Luis Mendoza

Kenan Christopher Garcia

David Baltimore

Michael Thomas Bethune

Michael Edward Birnbaum

Disclosed herein are compositions and methods for modulating IFN-γ-mediated signaling by completely or partially agonizing the downstream signal transduction mediated through at least one of the IFN-γ receptors. More particularly, the disclosure provides novel IFN-γ polypeptide variants with reduced binding affinity to at least one of its receptors. The disclosure also provides compositions and methods useful for producing such molecules, as well as methods for the treatment of health diseases associated with the perturbation of signal transduction mediated by IFN-γ.

Interferon-gamma biased agonists

Compositions and methods are provided for the identification of peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.

Ligand discovery for T cell receptors

Compositions and methods are provided relating to Type III interferons.

Variant type III interferons and synthekines

A tool shaped in a U-shape for accepting a standard U strut. The tool has opening for marking the strut for cutting purposes and hole openings for marking the center of standard struts.

Growing community of inventors

Redwood City, CA, United States of America

Juan Luis Mendoza