Medlumics S.l.

Juan Lloret Soler

Eduardo Margallo Balbás

José Luis Rubio Guivernau

Santiago Jiménez Valero

Alejandro Barriga Rivera

Juan Sancho Durá

Kirill Zinoviev

Justo Contreras Bermejo

William Kennedy Landles

Andrés Cifuentes

Blair Ungar

Eduardo Margallo BALBÁS

James L Greene

Jorge H Jimenez

José Luis Rubio Givernau

Juan Sancho Dura

Jose Luis Rubio Guivernau

Andres Cifuentes

Jose Luis Rubio Givernau

Santiago Jimenez Valero

Eduardo Margallo Balbas

Embodiments for crossing an occlusion by controlling a guide with the aid of optical coherence tomography (OCT) data are described. Embodiments include transmitting one or more beams of radiation via one or more waveguides on a flexible substrate within a guide wire. One or more beams of scattered or reflected radiation may be received from a sample via one or more waveguides. Depth-resolved optical data of the sample may be generated based on the received beams of scattered or reflected radiation. The depth-resolved data may be used for determining at least one of a distance between the guide wire and a wall of the artery and a distance between the guide wire and an occlusion within the artery. A position of the guide wire within the artery may then be controlled based on the determined distance or distances.

Crossing coronary occlusions

Systems and methods for performing RF ablation while monitoring the procedure using low coherence interferometry (LCI) data are described. A catheter includes a distal section, a proximal section, a multiplexer, and a sheath coupled between the distal section and the proximal section. The distal section includes one or more electrodes configured to apply RF energy to a portion of a sample in contact with the electrode. The distal section also includes a plurality of optical elements configured to transmit one or more beams of exposure radiation away from the distal section of the catheter. The proximal section includes an optical source configured to generate a source beam of radiation and a detector configured to generate depth-resolved optical data. The multiplexer is configured to generate the one or more beams of exposure radiation from the source beam of radiation.

Radiofrequency ablation catheter with optical tissue evaluation

Systems and methods for controlling a guide with the aid of optical coherence tomography (OCT) data are described. A guide wire includes at least one optical fiber, a flexible substrate, and one or more optical elements. The at least one optical fiber transmits a source beam of radiation. The flexible substrate includes a plurality of waveguides. At least one of the plurality of waveguides transmits one or more beams of radiation away from the guide wire, and at least one of the plurality of waveguides receives one or more beams of scattered radiation that have been reflected or scattered from a sample. The multiplexer generates the one or more beams of exposure radiation from the source beam of radiation. The one or more optical elements at least one of focus and steer the one or more beams of radiation.

Optical coherence tomography probe for crossing coronary occlusions

Systems and methods for performing RF ablation while monitoring the procedure using low coherence interferometry (LCI) data are described. A catheter includes a distal section, a proximal section, a multiplexer, and a sheath coupled between the distal section and the proximal section. The distal section includes several interconnected optical ports configured to transmit exposure radiation toward a sample and receive radiation that have been reflected or scattered from the sample. The interconnected optical ports are formed on a substrate having rigid sections and flexible sections arranged around the distal section. A holder maintains the interconnected optical elements in a fixed spatial relationship.

A chip package includes a housing, one or more electrical connections coupled to an exterior of the housing, a photonic integrated circuit, and a scanning unit. Both the photonic integrated circuit and the scanning unit are disposed within the housing. The photonic integrated circuit has at least one waveguide designed to guide a beam of light. The scanning unit is designed to laterally scan the beam of light across a focal plane outside of the housing. The scanning unit is aligned with the photonic integrated circuit such that the beam of light is coupled between the photonic integrated circuit and the scanning unit.

Miniaturized OCT package and assembly thereof

Systems and methods are presented for modulating a beam of radiation, such that the modulated beam exhibits substantially null residual amplitude modulation (RAM). An electro-optical modulator is presented that includes a waveguide, a first region associated with the waveguide and a second region associated with the waveguide. The waveguide is designed to guide a beam of radiation. A first electric potential applied to the first region causes a first modulation to the beam of radiation while a second electric potential applied to the second region causes a second modulation to the beam of radiation. The first modulation combined with the second modulation provides substantially null residual amplitude modulation of the beam of radiation.

Electro-optical silicon-based phase modulator with null residual amplitude modulation

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Madrid, Spain

Juan Lloret Soler