Proyecto De Biomedicina Cima, S.l.

Juan Jose Lasarte Sagastibelza

Jesus Prieto Valtuena

Francisco Borras Cuesta

Javier Dotor De Las Herrerías

Claude Leclerc

Marta Gorraiz Ayala

Ana Belen Lopez Vazquez

This invention relates to the use of a polypeptide in the production of an immunostimulatory agent, said polypeptide comprising a sequence corresponding to the EDA domain of fibronectin, a fragment of the EDA domain which can bind to TLR4 or a variant of said EDA domain or a fragment which can bind to TLR4 and which has a homology of more than 70% with any form or natural fragment of the EDA domain. The invention also relates to the production methods and applications of said agent.

Agents and methods based on the use of the EDA domain of fibronectin

The described peptides possess the capacity to bind to Transforming Growth Factor TGF-&#x3b2;1 (TGF-&#x3b2;1), and are potential inhibitors of the biological activity of TGF-&#x3b2;1 through direct binding to this cytokine. These peptides can be used in the treatment of diseases or pathological alterations based on excessive or deregulated TGF-&#x3b2;1 expression.

Peptides with the capacity to bind to transforming growth factor &#x3b2;1 (TGF-&#x3b2;1)

Growing community of inventors

Navarra, Spain

Juan Jose Lasarte Sagastibelza