Wisconsin Alumni Research Foundation

The University of Chicago

Western Digital Technologies, Inc.

Hgst Netherlands, B.v.

Government of the United States of America, as Represented by the Secretary of Commerce

University of Leiden

Juan Jose De Pablo

Paul Franklin Nealey

Mark Stoykovich

Huiman Kang

Marcus Muller

Konstantinos C Daoulas

David Charles Schwartz

Erik W Edwards

SangMin Park

Monirosadat Sadati

Thomas R Albrecht

Ricardo Ruiz

Kyubong Jo

Kristy Leigh Kounovsky-Shafer

Konstantinos Dimitrios Potamousis

Xiao Li

Theo Odijk

Rui Zhang

Francois Detcheverry

Juan Pablo Hernandez-Ortiz

Ye Zhou

Tadej Emersic

Gustavo Andres Vasquez Montoya

Nader Taheri Qazvini

Tushar S Jain

Jose A Martinez-Gonzalez

Eileen T Dimalanta

Nicholas Lawrence Abbott

Christopher John Murphy

Frank Steven Bates

Hiroshi Yoshida

Nathan Lockwood

Sean Paul Palecek

Jeffrey C Mohr

Guoliang Liu

Paul Barth Conrad

Sidney Robert Nagel

Elise Huang

Heinrich Jaeger

Matthew Tirrell

Christopher Lloyd Soles

Johnny D Alfaro-Perez

SangOuk Kim

Meng Shen

Marcos A Reyes-Martinez

Daniel Hexner

Andrea Jo-Wei Liu

Carl Goodrich

Daniel Robert Reid

Nidhi Pashine

Irmgard Bischofberger

Edwin Pak-Nin Chan

Yashuhiko Tada

Abelardo Ramirez-Hernandez

Horacio Corti

Optofluidic devices configured confine liquid crystals within a fluidic channel under the application of acoustic waves and pressure-driven flow and related methods of use are described.

Molecular reorientation of liquid crystals using acoustic waves and fluid flow in confinement

Provided herein are polymer-stabilized CaP nanoparticle formulations and related methods of manufacture. In certain embodiments, the methods reliably and selectively form nanoparticles with homogenous size, charge, and morphology. The CaP nanoparticles include calcium ions and phosphate ions with an ionic polymer, thereby forming stable hybrid nanoparticles. The CaP nanoparticle formulations include powders, suspensions and injectable pastes. According to various embodiments, the polymer-stabilized CaP nanoparticles may be polycation-stabilized (CaP/polymer(+) nanoparticles) or polyanion-stabilized (CaP/polymer(−) nanoparticles). The CaP/polymer nanoparticles can be freeze-dried and stored for months with no loss of properties or changes to their morphology.

Injectable pastes based on oppositely charged polymer/calcium phosphate nanoparticles

Provided are freeze-dried (FD) products of biological materials that have improved stability and reduced risk of collapse. The FD products include nanoparticles that are added to formulations including the biological materials prior to freeze-drying. Also described herein are methods of freeze-drying (FD).

Freeze-dried formulations including nanoparticles and methods of freeze-drying

Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.

Blue phases on patterned surfaces

Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.

System and method for en masse patterning of molecule structures

An inverse design machine for making a manufactured article that includes a designer Impact-mitigating architectured isotropic structure includes: an input unit that receives a primary structure; a primary structure analyzer that receives the primary structure from the input unit and determines primary properties of the primary structure; a structure adjuster that receives the primary properties from the primary structure analyzer, receives impact-mitigating properties from a structural property manager, and produces the designer Impact-mitigating architectured isotropic structure from the impact-mitigating properties; and the structural property manager that provides the impact-mitigating properties to the structure adjuster.

Inverse design machine and making a designer impact-mitigating architectured isotropic structure

Methods to pattern substrates with dense periodic nanostructures that combine top-down lithographic tools and self-assembling block copolymer materials are provided. According to various embodiments, the methods involve chemically patterning a substrate, depositing a block copolymer film on the chemically patterned imaging layer, and allowing the block copolymer to self-assemble in the presence of the chemically patterned substrate, thereby producing a pattern in the block copolymer film that is improved over the substrate pattern in terms feature size, shape, and uniformity, as well as regular spacing between arrays of features and between the features within each array compared to the substrate pattern. In certain embodiments, the density and total number of pattern features in the block copolymer film is also increased. High density and quality nanoimprint templates and other nanopatterned structures are also provided.

Density multiplication and improved lithography by directed block copolymer assembly

Provided are methods of fabricating thin film structures that involve assembling block copolymer materials in the presence of condensed phase surfaces on both sides of the thin film, at least one of which is a chemically patterned surface configured to direct the assembly of the block copolymer material. According to various embodiments, the other of the condensed phase surfaces can be a chemically homogenous surface or a chemically patterned surface. Also provided are structures, morphologies, and templates formed in the domain structure of block copolymer materials. In certain embodiments, complex 3-D morphologies and related structures not present in bulk block copolymer materials are provided.

Directed assembly of block copolymer films between a chemically patterned surface and a second surface

Methods of fabricating complex three-dimensional structures on patterned substrates and related compositions are provided. The methods involve depositing on the substrate a block copolymer material that is 'mismatched' to the substrate pattern, and then ordering the material to form a complex three-dimensional structure. According to various embodiments, the copolymer material mismatches the substrate pattern in that the symmetry and/or length scale of its bulk morphology differs from that of the pattern. When ordered, a balance between the physics that determines the bulk block copolymer morphology and the physics that determines the substrate surface interfacial interactions results in a thermodynamically stable complex three-dimensional film that varies in a direction perpendicular to the substrate and has a morphology that differs from its bulk morphology.

Fabrication of complex three-dimensional structures based on directed assembly of self-assembling materials on activated two-dimensional templates

Methods of directed self-assembly of multi-block (i.e., triblock and higher-order) copolymers on patterned substrates and related compositions are provided. According to various embodiments, the methods involve depositing copolymer materials on substrates configured to drive the assembly of micro-phase separated films that exhibit the same morphology as that copolymer materials in the bulk. In certain embodiments, binary patterns are used to drive the triblock copolymer films. The binary two-dimensional surface patterns are transformed into three-component and three-dimensional structures throughout the thickness of the overlying copolymer films.

Directed assembly of triblock copolymers

Growing community of inventors

Madison, WI, United States of America

Juan Jose De Pablo