University of California

Juan E Diaz

James A Wells

Gregory A Weiss

Jessica A Arter

Alexander J Martinko

Michael J Hornsby

The disclosure is related to antibodies and antibody fragments that specifically bind the CUB domain-containing protein 1 (CDCP1) and their methods and uses in treating and detecting cancers.

Antibodies against CDCP1 for the treatment and detection of cancer

The invention described herein features methods of isolating monoclonal antibodies or polypeptides that bind to a cell surface expressed antigen. The method of catch and release utilizes engineered protease site for cleavage antigen-antibody or antigen-polypeptide complexes. In some embodiments the protease cleavage site to cleave the complexes is an exogenous protease to mammalian cell. In various embodiments the protease cleavage site to cleave the complexes is an endogenous protease to mammalian cell.

Proteolytic release of cell surface antigens for phage biopanning

PSMA ligands, compositions, and methods therefore are disclosed where the ligand is a peptide having the sequence XXCVEVXQNSCXXwhere X-Xare independently a natural or non-natural amino acid or a peptide having the sequence CALCEFLG [SEQ ID NO: 1]. Especially preferred aspects include diagnostic reagents for detection and/or quantification of PSMA in a sample, therapeutic reagents, and diagnostic imaging reagents.

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San Francisco, CA, United States of America

Juan E Diaz