Consejo Superior De Investigaciones Cientificas

Universidad De Granada

Traslational Cancer Drugs Pharma, S.l.

Juan Carlos Lacal Sanjuán

Ana Ramirez De Molina

David Gallego Ortega

Mónica Bañez Coronel

Joaquin Campos Rosa

Miguel Ángel Gallo Meza

Antonio Espinosa Ubeda

Miguel Ángel Gallo Mezo

Antonio Espinosa Úbeda

Mónica Báñez Coronel

Ana Ramìrez De Molina

Lourdes García Oroz

Miguel Angel Universidad De Granada Gallo Meza

Joaquin Universidad De Granada Campos Rosa

Antonio Universidad De Granada Espinosa Ubeda

The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder cancer in an individual, for determining the stage or severity of said cancer in the individual, or for monitoring the effect of the therapy administered to an individual having said cancer; to finding, identifying, developing and evaluating the efficacy of compounds for the therapy of said cancer, for the purpose of developing new medicinal products; as well as to agents inhibiting the expression and/or activity of the choline kinase alpha protein and/or the effects of this expression.

Method for identifying compounds for cancer therapy

The invention provides compounds of formula I blocking phosphorylcholine biosynthesis by means of the selective blocking of the choline kinase enzyme in tumor cells or in cells affected by parasitic infection and therefore being applicable in the treatment of tumors and parasitic diseases or diseases produced by viruses and fungi in animals, including human beings; as well as to a method for preparing the compounds of the invention and certain intermediates of said method.

Pyridinium and quinolinium derivatives

In vitro method for identifying compounds for cancer therapy

Derivatives of pyridine and quinoline

Growing community of inventors

Madrid, Spain

Juan Carlos Lacal Sanjuán