Baylor College of Medicine

European Molecular Biology Laboratory

Vitruvean LLC

Juan Botas

Huda Y Zoghbi

Luis Serrano

Christian Boulin

Christopher J Cummings

Cayetano Gonzalez

Ismael Al-Ramahi

Diego Rincon-Limas

Edward Faeldt

Pedro Fernandez-Funez

The present invention provides a method for screening for the effect of a test agent on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, creating a digitized movie showing the movements of members of the population, measuring at least one trait of members of the population, and correlating the traits of the population with the effect of the test agent. The invention also provides a method for preparing a medicament useful for the treatment of a mammalian disease.

Method for identification of biologically active agents

The present invention discloses a double transgenic fly that expresses both Tau protein and the human A&#x3b2;42 peptide of human amyloid-&#x3b2; precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared to the altered phenotype displayed by transgenic flies expressing either Tau or human A&#x3b2;42 alone, and thus provide for an improved model for neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying for therapeutic compounds to treat neurodegenerative disorders using the double transgenic flies.

Model for neurodegenerative disorders

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Houston, TX, United States of America

Juan Botas