The United States of America As Represented by the Department of Health

The United States of America As Represented by the Secretary of

Industriale Chimica S.r.l.

Juan B Rodriguez

Victor E Marquez

Marc C Nicklaus

Joseph J Barchi, Jr

Maqbool A Siddiqui

Roberto Lenna

Javier Alberto Ramirez

Francesca Costantino

Maria Julieta Comin

A process is described for preparing, exclusively by chemical way, 21-hydroxy steroids having progestinic activity, said process having a high stereochemical control at C-21 position.

Process for the preparation of 21-hydroxy steroids with control of the epimeric distribution at the C-21 position

Conformationally locked 4',6'-cyclopropane-fused carboxylic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine, and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.

Conformationally locked nucleoside analogues

A method for treatment of herpes virus infection by administering an effective virus-inhibiting amount of a cyclopropanated carbocyclic 2'-deoxynucleoside to an individual in need thereof. The nucleoside analogs are effective against herpes simplex virus types 1 and 2; Epstein-Barr Virus and human cytomegalovirus.

Conformationally locked nucleoside analogs as antiherpetic agents

Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.

Growing community of inventors

Buenos Aires, Argentina

Juan B Rodriguez