Fundacion Para La Investigacion Medica Aplicada

Fundación La Investigación Médica Aplicada

Juan Antonio Sánchez Arias

Julen Oyarzabal Santamarina

Maria Obdulia Rabal Gracia

Felipe Prósper Cardoso

Edurne San José Enériz

María Del Mar Cuadrado Tejedor

Xabier Aguirre Ena

Ana María García Osta

Ana Ugarte Baztán

It relates to the compounds of formula (I), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein A, R, R, and Rare as defined herein, which are inhibitors of one or more DNMTs selected from the group consisting of DNMT1, DNMT3A and DNMT3B. It also relates to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer, fibrosis and/or immunomodulation. 

Compounds as inhibitors of DNA methyltransferases

Novel compounds for use in cognition improvement It relates to certain compounds having a polycyclic structure and a &#x2014;(C&#x2550;O)NRRmoiety, wherein the polycyclic structure comprises at least three ring systems, wherein one ring system is a polycyclic ring system comprising from 2 to 4 rings; at least one ring is an aromatic ring; and wherein the structure comprises at least 3 nitrogen atoms and 1 oxygen atom. It also relates to pharmaceutical compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of neurological disorders coursing with a cognition deficit or impairment, or neurode-generative diseases.

Compounds for use in cognition improvement

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Pamplona, Spain

Juan Antonio Sánchez Arias