Novartis Ag

University of Pennsylvania

Ju Young Kim

Jennifer Bordeaux

Naveen Kumar Dakappagari

Thai Tran

Carl H June

Ming Lei

Andreas Loew

Jennifer Brogdon

Saar Gill

Marco Ruella

Lu Huang

Li Zhou

Jimin Zhang

Na Li

Elena Orlando

Hans Bitter

Steven Highfill

Barbara Brannetti

Brian Little

Jennifer Mary Bordeaux

The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.

CD20 therapies, CD22 therapies, and combination therapies with a CD19 chimeric antigen receptor (CAR)-expressing cell

The invention relates, in part, to methods of scoring a sample containing tumor tissue from a cancer patient. The score is representative of a spatial proximity between at least one pair of cells, a first member of the at least one pair of cells expressing a first biomarker and a second member of the at least one pair of cells expressing a second biomarker that is different from the first biomarker. The score obtained from these methods can be indicative of a likelihood that a patient may respond positively to immunotherapy.

Method of scoring a sample comprising tumor tissue

The invention relates, in part, to methods of deriving a value for % biomarker positivity (PBP) for all cells or optionally, one or more subsets thereof, present in a field of view of a tissue sample from a cancer patient. The values for PBP can be indicative of a patient's response to immunotherapy.

Method of deriving a value for percent biomarker positivity for selected cells present in a field of view

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Carlsbad, CA, United States of America

Ju Young Kim