Dong-a Pharm. Co., Ltd.

College of Medicine Pochon Cha University Industry-Academic Cooperation Foundation

Chabio & Diostech Co., Ltd

Ju-Mi Kim

Dong-Sung Kim

Yong-duck Kim

Jeong-Hoon Kim

Soo-Hong Lee

Moo-Hi Yoo

Sun-Woo Jang

Sung-Hwan Moon

Kyung-Koo Kang

Byoung-Ok Ahn

Mi-Jeong Seo

Seul-Min Choi

Yong-Sung Shon

Hyung-Min Chung

Yong-Duck Kim

The present invention provides a 3',4&#x2032;,5-trimethoxy flavone derivative and a pharmaceutically acceptable salt thereof, preparation thereof, and a pharmaceutical composition for the treatment and prevention of dry eye syndrome comprising the same as an active ingredient. The 3&#x2032;,4&#x2032;,5-trimethoxy flavone derivative and its pharmaceutically acceptable salt inhibit corneal damage through excellent stimulatory action on mucus secretion in the conjunctiva and therefore may be effective as a prophylactic or therapeutic agent for dry eye syndrome.

3',4&#x2032;,5-trimethoxy flavone derivatives as stimulant of mucus secretion, method for the same, and pharmaceutical composition comprising the same

The present invention provides a process for isolating vascular endothelial cells from embryoid bodies differentiated from embryonic stem cells, which comprises: (a) treating embryoid bodies differentiated from embryonic stem cells with 0.005-0.015% trypsin and 0.05-0.15 mM ethylenediaminetetraacetate (EDTA) to obtain vascular endothelial cell clusters; and (b) treating the vascular endothelial cell clusters with 0.1-0.5% trypsin and 0.5-2 mM EDTA so as to separate the vascular endothelial cell clusters into single cells.

Process for isolating vascular endothelial cells from embryoid bodies differentiated from embryonc stem cells

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Yongin-si, South Korea

Ju-Mi Kim