Abbott Laboratories Corporation

Abbvie Inc.

Ju Gao

Philip R Kym

Andrew J Souers

Dariusz Wodka

Christine Ann Collins

Anil Vasudevan

Rajesh R Iyengar

Mathew M Mulhern

Hing L Sham

Zhili Xin

Todd M Hansen

Zhonghua Pei

Bo Liu

Vince S Yeh

Andrew S Judd

Gang Zhao

Mary Katherin Verzal

Michael A Patane

Matthew J LaMarche

Martin P Maguire

Su-Jen Lai

Irini Akritopoulou-Zanze

Christopher Blackburn

Courtney A Cullis

Kresna Hartandi

John K Lynch

Jennifer C Freeman

James A Brown

Kathleen M Phelan

Jared C Lewis

Jennifer L Che

Matthew J Lamarche

James Brown

Mary Katherine Verzal

Bo X Liu

Todd Matthew Hansen

Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseases or conditions.

Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme

The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, a pharmaceutical composition of formula (I), and related methods for treating or preventing metabolic diseases or conditions.

The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor

The present invention is related to compounds of formula (I),or a therapeutically suitable salt or prodrug thereof, which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor and are useful for the prevention or treatment of eating disorders, weight gain and obesity.

2-Aminoquinolines as melanin concentrating hormone receptor antagonists

This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula I:where m is zero or one, n is zero to two, Y is oxygen or &#x2014;N(R)&#x2014;, R, R, R, R, R, Rand Ring A are defined in the specification. Coumarin and quinolone compounds where Rand Rtogether form a fused benzo ring are preferred. The invention also provides compounds of formula VI where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.

Antagonists of melanin concentrating hormone receptor

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Gurnee, IL, United States of America

Ju Gao