Cj Cheiljedang Corporation

Ju Eun Kim

Yong Uk Shin

In Kyung Heo

Sung Kwang Son

Kwang Ho Na

Han Jin Lee

Seung Hyun Cho

Jae Min Lee

Ji Hye Lee

So Young Kim

Chang Il Seo

Hyun Ah Kim

Sang Mok Lee

Jae Hee Lee

Sung Hoo Jhon

Jee Yeon Bae

Ji Hyun Lee

Hyung Joon Kim

Jin Sook Chang

Min Ji Baek

Chang Gyeom Kim

Byoung Hoon Yoon

Il Chul Kim

Kyungrim Kim

Nara Kwon

Hyo Jeong Byun

Su Yon Kwon

Hyun-jung Bae

The present disclosure relates to a microorganism of the genushaving an increased L-amino acid producing ability, containing NADP-dependent glyceraldehyde-3-phosphate dehydrogenase derived from the genus. According to the present disclosure, the NADP-dependent glyceraldehyde-3-phosphate dehydrogenase derived fromsubsp.is introduced to increase the reducing power through the activity of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, thereby increasing the L-amino acid producing ability of the strains belonging to the genus

Method for producing L-amino acids using microorganism containing NADP-dependent glyceraldehyde-3-phosphate dehydrogenase

The present invention relates to a recombinant microorganism producing quinolinic acid, more particularly, a microorganism producing quinolinic acid and having attenuated activity or eliminated activity of a protein having a sequence of SEQ ID NO: 1 and a method of producing quinolinic acid by using the recombinant microorganism.

Recombinant microorganism producing quinolinic acid and method for producing quinolinic acid using same

The present invention relates to a quinolinic acid-producing recombinant microorganism expressing a fusion protein of L-aspartate oxidase and quinolinate synthase linked via a linker, and a method for producing quinolinic acid using the same.

Recombinant microorganism producing quinolinic acid and a method for producing quinolinic acid using the same

A method for the preparation of nicotinic acid, which includes the step of obtaining a culture solution containing quinolinic acid by incubating a microorganism having an ability to produce quinolinic acid, and the step of adding an acid to the culture solution and conducting a decarboxylation reaction.

Method for the preparation of nicotinic acid

To produce quinolinate effectively, a L-aspartate oxidase variant that the feedback regulation by nicotinic acid or NAD is released, and a microorganism including the L-aspartate oxidase variant are provided. Quinolinate may be effectively produced by culturing of the microorganism including the L-aspartate oxidase variant.

L-aspartate oxidase variant and a method for producing quinolinate or nicotinic acid using the same

The present invention relates to a polypeptide that is modified to have homoserine O-acetyltransferase activity, and in particular, the present invention provides a modified polypeptide having homoserine O-acetyltransferase activity, in which the amino acid at position 111 of a polypeptide having homoserine succinyltransferase activity is substituted with other amino acid.

Modified polypeptide having homoserine acetyltransferase activity and microorganism expressing the same

The present invention relates to a novel protein having O-acetylhomoserine sulfhydrylase activity, a mutant protein thereof, a polynucleotide encoding the same, a recombinant vector comprising the polynucleotide, a microorganism transformed with the recombinant vector, and a method for producing methionine or acetic acid using the protein. The production method of the present invention has the advantage of producing L-methionine and acetic acid cost-effectively through having higher conversion rate and reduced reaction time compared to the existing methods, and it can minimize the amount of enzyme homogenate added when using the mutant protein, thereby easily producing L-methionine and acetic acid at high yield.

O-acetylhomoserine sulfhydrylase or mutant protein thereof, and method for converting to methionine using the same

The present invention relates to a method for increasing L-methionine productivity and organic acid productivity. More particularly, the present invention relates to a method which involves adding a mixture containing methyl mercaptan and dimethyl sulfide at a appropriate ratio to O-acetyl homoserine or O-succinyl homoserine and to an enzyme having an activity of converting methionine precursor into L-methionine, so as to perform an enzyme reaction, to thereby improve the conversion rate of L-methionine and organic acid from the L-methionine precursor, and thus increasing L-methionine yield as compared to conventional method.

Method for increasing methionine productivity using a mixture of methyl mercaptan and dimethyl sulfide

Disclosed herein are a microorganism strain capable of producing the L-methionine precursor O-acetyl homoserine in high yield and a method of producing O-acetyl homoserine using the same. The microorganism strain is a strain ofsp. in which an acetyl-CoA synthase gene (acs) and/or a pantothenate kinase gene (coaA) encoding a pantothenate kinase gene refractory to feedback inhibition by CoA is introduced and expressed.

Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism

Disclosed is a strain ofsp., capable of producing O-acetyl homoserine in high yield, with the introduction and enhancement therein of the activity of: homoserine acetyl transferase, aspartokinase and homoserine dehydrogenase; and at least one enzyme selected from a group consisting of phosphoenolpyruvate carboxylase, aspartate aminotransferase and aspartate semi-aldehyde dehydrogenase. Also, a method of producing O-acetyl homoserine using the strain is provided.

Growing community of inventors

Seoul, South Korea

Ju Eun Kim