Biosurfit S.a.

João Manuel De Oliveira Garcia Da Fonseca

André Do Rosário Magalhães

José Pedro Santos Manso Côrte-Real

Ricardo Manuel Marques Caleiro Cabeça

Francisco Correia De Matos Nolasco Lamas

Tiago Filipe Pinto Silva

Sandro Miguel Pinto Bordeira

José Miguel Silva Do Carmo Nogueira

Filipe Da Conceição Fernandes Thomaz

Alberto Eduardo Artilheiro Ferreira

Mauro Miguel Melo Ribeiro

André Miguel Alves Farinha

Ricardo Cabeça

Sandra Cristina Sarmento Donato Dos Santos E Silva

Andreia Andrade Dos Santos

Ricardo Manuel Marquest Caleiro Cabeca

José Pedro Santos Manso Co̊rte-Real

José Pedro Santos Manso Côrte-real

Miguel Tavares Aleluia

Milton José Santos Fernandes

Filipe Da CONCEIÇÃO Fernandes Thomaz

Rui Miguel Afonso Gomes Da Fonseca

Ricardo Manuel Marques Caleiro Cabeca

José Pedro Santos Manso CÔRTE-Real

André Do ROSÁRIO MAGALHÃES

Ricardo CABEÇA

A detection system including a detection device and an assay device. The detection device includes a space for receiving an assay device, a drive arrangement engaging the assay device to rotate the assay device, a light source arranged to direct light towards the assay device, and a diffuser arranged to diffuse light from the light source. The diffuser is arranged between the light source and the space. The detection device includes a light receiver arranged to receive light from the light source that has passed through the assay device.

Detection method

Systems and methods for classifying blood cells in a blood sample are disclosed. A series of frames of the blood sample as it flows through a field of view of an image capture device are captured and analysed. Advantageously, the disclosed systems and methods combine the availability of morphological cell data with the convenience of a flow-through arrangement. The classification results can be used for estimating cell counts in a blood sample.

Cell counting

Systems and related methods of imaging and classifying cells in a blood sample

Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.

Binding assay signal analysis

A microfluidic device with reduced risk of bubble formation at a capillary junction between two conduits is provided. In some embodiments, the microfluidic device comprises a supply reservoir, a first conduit and a second conduit. The first conduit is configured such that liquid flows by capillary effect from the supply reservoir into the first conduit. The second conduit is connected to the first conduit through an opening in a wall of the first conduit and is configured such that liquid flows from the first conduit to the second conduit by capillary effect. A width of the second conduit, along a direction of liquid flow in the first conduit, is greater than a depth of the second conduit and a depth of the second conduit is less than a depth of the first conduit.

Capillary junction

A device for use in imaging a liquid sample comprises an inlet for accepting the sample, a connection conduit and a detection chamber for detection of the sample, preferably optical detection of the sample. The connection conduit connects the inlet to the detection chamber and contains one or more dry reagents for reaction with the sample as the sample passes through the connection conduit. Specific embodiments include devices arranged for treating a blood sample, in particular lysing and staining the sample. The liquid flow may be driven by capillary effect. The device may further include liquid handling structures arranged for centrifugally driven liquid flow, for example to meter a volume of sample and separate the sample into phases by centrifugation.

Blood cell counting device and method

Growing community of inventors

Azambuja, Portugal

João Manuel De Oliveira Garcia Da Fonseca