Egis Gyogyszergyar

Egis Gyogyszergyar Rt.

Other

Richter Gedeon Vegyeszeti Gyar Rt

Biogal Gyogyszergyar

Gis Gyogyszergyar Rt.

Jozsef Reiter

Istvan Gyertyan

Marton Fekete

Gabor Gigler

Istvan Gacsalyi

Lujza E Petocz

Frigyes Gorgenyi

Gyula Simig

Jozsef Barkoczy

Laszlo Pongo

Pal Vago

Endre Rivo

Imre Moravcsik

Ferenc Andrasi

Gabor Blasko

Eniko Szirt Nee Kiszelly

Tamas Hamori

Pal Berzsenyi

Lajos Toldy

Klara Reiter Nee Esses

Tibor Lang

Gabor Zolyomi

Eszter Szentkuti

Anna Bakonyi

Katalin Horvath

Edit Horvath

Gyorgyne Mate

Kalman Harsanyi

Zoltan Budai

Bela Hegedus

Gyorgy Fekete

Tibor Balogh

Gyorgy Domany

Endre Kasztreiner

Kalman Nagy

Pal Fekete

Istvan Horvath

Eva Againe Csongor

Ferenc Lorant Bartha

Janos Borvendeg

Andras Egyed

Peter Tompe

Geza Szilagyi

Maria Szecsey Nee Hegedus

Gyorgy Somogyi

Gizella Zsila

Margit Csorgo

Margit Bidlo Nee Igloy

Laszlo Gaal

Karoly Tihanyi

Andras Bilkei-Gorzo

Ferenc Morasz

Judit Bajnogel

Janos Brlik

Eva Szabo

Gabor Makara

Andras Rado

Maria Kiraly Nee Ignacz

Ilona Sztruhar

Enik Szirt Nee Kiszelly

Arpad Lazar

Peter Slegel

Szilveszter E Vizi

Norbert Nemeth

Tibor Somogyi

Klara Reiter Nee Esess

Frigyes Gogenyi

Oszkar Fuchs

Klara Daroczi Kazone

Hilda Botka

Peter Korosi

Cecilia Salamon Haskane

Tamas Somorai

Dezso Danyi

Szvetlana Zsarnoczai Nee Kurnyecova

Sarolta Benko Nee Markus

Magdolna Kenyeres Nee Feher

Agnes Halbauer Nee Nagy

Margit Csorg

Ludmila Rohacs Nee Zamkovaja

Maria Szecsey Nee Heged S

Gabor Berecz

Lujza Pet Cz

Gyōrgyi Vereczkeyne Donath

Gyōrgy Clementis

Peter Tömpe

Jeno Korosi, Deceased

Peter Botka, Deceased

Erszebet Birkas

The invention refers to a novel process for the preparation of {2-[-(&#x3b1;-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid, which comprises hydrolyzing an N,N-disubstituted {2-[-(&#x3b1;-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetamide, wherein said substituents are selected from alkyl groups having 1 to 4 carbon atoms optionally substituted by a phenyl group, alkenyl groups having 2 to 4 carbon atoms or cyclohexyl groups, or the substituents together with the adjacent nitrogen atom of the acetoamido group, form a morpholino group.

Process for the preparation of {2-[4-&#x3b1;-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy} acetic acid and novel intermediates therefor

The invention relates to new 1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof and pharmaceutical compositions comprising them. The new 1-[2-(substituted vinyl)]-3,4-dihidro-5H-2,3-benzodiazepine derivatives according to the invention correspond to the general formula (I), ##STR1## wherein the variables are hereinbelow defined: The new compounds according to the invention affect the central nervous system and can be used to advantage in the therapy.

1-[2-(substituted vinyl)]-3,4-dihydro-4-dihydro-5H-2,3-benzodiazepine

This invention relates to new 1-�2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said benzodiazepine derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The compounds according to the invention correspond to the general formula (I), ##STR1## wherein the variables are herein below defined, and the compounds possess central nervous activities.

1-�2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives

Acid amide derivatives and process for the preparation thereof

The disclosed compounds have the formula ##STR1## wherein Q is a 6-membered saturated heterocyclic group or a group S(O)pR.sup.3, wherein

5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives

This invention relates to a new and improved process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]-quinazolin-2[3H]-one of formula ##STR1## (anagrelide), a valuable blood platelet antiaggregative compound. According to the process of the invention the compound of formula (I) is prepared by subjecting a new 2-cyanoiminoquinazoline derivative of the general formula ##STR2## wherein R stands for cyano or a group of the formula COOR.sup.1, in the latter R.sup.1 representing lower alkyl optionally carrying a phenyl substituent, to thermal cyclization in an acidic medium. The invention also relates to new 2-cyanoiminoquinazo-lines of the general formula (III) used for the production of anagrelide and to the preparation of the said compounds. The invention provides an advantageous process for the preparation of anagrelide which is devoid of the drawbacks of the hitherto known processes and renders possible the production of the compound of the formula (I) on industrial scale, too.

Process for the preparation of

This invention relates to novel triazolyl hydrazide derivatives and a process for the preparation thereof. The new triazolyl hydrazide derivatives of the general formula (I). ##STR1## wherein Q represents hydrogen or a heterocyclic group optionally substituted by a C.sub.1-4 alkyl group; or a group of general formula SR.sup.1, wherein

Triazolyl hydrazide derivatives

The invention relates to novel triazolyl thioamides of the general formula (I), ##STR1## wherein Q represents hydrogen or a heterocyclic group optionally bearing one or more C.sub.1-4 alkyl substituent(s), or a group of the formula SR.sup.1, wherein

Triazolyl thioamide derivates

This invention relates to novel triazolo derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said triazolo derivatives for the treatment of diseases and also for the preparation of pharmaceutical compositions suitable for the treatment of the said diseases. The new triazolo derivatives of the general formulae (Ia) and (Ib), ##STR1## wherein Q represents hydrogen or a heterocyclic group optionally bearing one or more C.sub.1-4 alkyl substituent(s); or a group of the formula SR.sup.1, wherein

Triazolo derivatives and process for their preparation

This invention relates to novel triazolopyrimidine derivatives of formulae (Ia) and (Ib), ##STR1## wherein Q represents hydrogen, a heterocyclic group optionally substituted by a C.sub.1-4 alkyl group and containing one or more oxygen and/or nitrogen atoms or a group of formula

Novel triazolo-pyrimidine derivatives

The invention relates to condensed cyclic triazole derivatives of the general Formula I ##STR1## and pharmaceutically acceptable salts thereof. The compounds of the general Formula I possess useful sedative and tranquillant properties and exhibit particularly spasmolytic, motility inhibiting, and narcosis potentiating, yohimbine potentiating and local anaesthetic and also weak reserpine ptosis inhibiting effect.

Condensed cyclic triazole derivatives, pharmaceutical compositions and

The invention relates to the new monohydrate of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne (cimetidine), a histamine-H.sub.2 receptor antagonist which is called N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne H (cimetidine H) as well as to a process for the preparation of same, which comprises pouring a hot, homogeneous aqueous solution of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne, optionally containing also methylamine, onto ice and separating the N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne monohydrate.

Cimetidine monohydrate

The invention relates to acylated 1,2,4-triazole derivatives of general formula I ##STR1## wherein R.sup.1 represents an unsubstituted phenyl group or a phenyl group substituted by one or more halogen atoms, lower alkyl, alkoxy, acyloxy, hydroxy, amino, azido, nitro, trifluoromethyl, lower alkylthio, alkylsulfinyl, or alkylsulfonyl group, and

Antiviral acylated 1,2,4-triazole derivatives

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Budapest, Hungary

Jozsef Reiter