Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Jozsef Nemes

Rudolf Soos

Miklos Szelestei

Laszlo Vidra

Gabor Kovacs

Istvan Szekely

Tamas Szuts

Peter Szentmiklosi

Laszlo Toke

Jeno Marton

Jozsef Lengyel

Ferenc Faigl

Elemer Fogassy

Rezso Kolta

Peter Sarkozi

Istvan Szekeley

Eniko Schreiner Nee Kovats

Jozsef Bozzay

Erzsebet Babos Nee Vajas

Peter Bencsik

Istvan Schler

This invention relates to a primycin-containing colloidal basic gel comprising 5-30% of primycin and 95-70% of N-methyl-pyrrolidone-2. The invention also relates to antibacterial compositions particularly for the treatment of acne vulgaris comprising as active ingredient 0.1-100% of a primycin-containing colloidal basic gel, if desired together with further antimicrobial active ingredients, in admixture with 99.9-0% of usual inert pharmaceutical filling, diluting and other formulating additives. The invention also relates to combination composition comprising as active ingredient 1-60% of a primycin-containing colloidal basic gel and 0.1-40% of further pharmaceutical active ingredient(s), e.g. one or more antibiotic(s), chemotherapeutical agent(s), fungistatic or fungicidal agent(s), steroidal or non-steroidal antiinflammatory agent (s), epithelogenic agent(s), local anaesthetic(s), and/or vitamin(s).

Primycin-containing colloidal basic gel

The invention is directed to a new process for the preparation of carbinols of the general formula I ##STR1## by reaction chloral and olefins of the general formula ##STR2## and by optional acylation of the product comprising dissolving a catalyst of the general formula III

Process for the preparation of trichloromethyl carbinols

The invention relates to a process for the preparation of enantiomers of trans vinyl-cyclopropane carboxylic acids of the formula I, ##STR1## wherein R is a methyl group or chlorine atom, by resolution of racemic trans compound or mixture of racemic cis and trans compounds by using (+)- or (-)-N-(1-formamido-2,2,2-trichloroethyl)-piperazine as a resolving agent in a polar solvent then separating the crystallizing salt of (+)-trans carboxylic acid and (-)-resolving agent or (-)-trans carboxylic acid and (+)-resolving agent from the mother liquor by filtration and obtaining the enantiomers by acidifying the mother liquor or the salts suspended in water followed by extraction with a solvent and evaporation. The products so obtained may be used as starting materials for the preparation of insecticides.

Process for the preparation of optically active cyclopropane carboxylic

The invention relates to a new process for preparing unsaturated geminal dihalogen compounds. More particularly, the invention concerns a process for preparing compounds of the formula (I) ##STR1## wherein X is halogen,

Process for the preparation of unsaturated geminal dihalogen compounds

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Budapest, Hungary

Jozsef Nemes