Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Kabi Pharmacia Ab

Chinoin, Ltd.

Jozsef Ivanics

Gabor Kovacs

Istvan Stadler

Vilmos Simonidesz

Geza Galambos

Sandor Virag

Gyorgy Dorman

Agnes Papp Nee Behr

Karoly Kanay

Istvan Hermecz

Istvan Szekely

Tibor Szabo

Peter S Kormoczy

Istvan Tomoskozi

Istvan Pallagi

Gyula Dalmadi

Karoly Horvath

Peter Gyory

Pal Hadhazy

Krisztina Kekesi

Ildiko Szilagyi

Gaborne Kovacs

Peter Kormoczi

Judit Skopal

Resul Bahram

Julia Der Nee Foldvary

Gaza Galambos

Peter Kormoczky

Marianna Kovacs

Istvan Tomoskozy

Jozsefne Ivanics

Miklos Kiss

The invention relates to a novel process for the preparation of 13,14-dihydro-15 (R)-17-phenyl-18,19,20-trinor-PGF.sub.2.alpha. isopropyl ester of the formula (I)--wherein R stands for saturated or unsaturated straight, branched or cyclic C.sub.1-7 alkyl or phenyl or benzyl group-- ##STR1##

Process for the preparation of

The invention relates to novel interfuranylene-prostacyclin derivatives of the general formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or a straight or branched chain C.sub.1-6 alkyl group, an inorganic cation or for the protonated form of a base containing an amino group;

Interfuranylene prostacyclins

Compounds of the formula ##STR1## are disclosed wherein R.sup.1 stands for hydrogen, C.sub.1-4 straight or branched alkyl or pharmacologically acceptable cation, R.sup.2 stands for hydrogen, C.sub.1-4 alkanoyl, benzoyl, or benzoyl substituted by C.sub.1-4 alkyl or halogen, and R.sup.2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or --C.dbd.C--, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.

Selective biologically active 7-oxo-prostacyclin derivatives and

New PGI.sub.1 derivatives are disclosed as well as a process for the preparation thereof, pharmaceutical compositions containing same and methods of treatment employing same. The new compounds are useful to inhibit blood platelet aggregation induced by ADF, arachidic acid, or collagen, as well as to improve blood circulation and to inhibit gastric acid secretion.

5-Substituted-4-oxo-PGI.sub.1 derivatives, PGI.sub.1 compounds of

The invention relates to a process for the preparation of novel 4-oxo-PGI.sub.2 derivatives of formula I ##STR1## where (a) compounds of formula III ##STR2## are oxidized, then the obtained 5-substituted-4-oxo-PGI.sub.1 derivatives of general formula II ##STR3## are eliminated by the splitting off of the W-H-molecule, or (b) the compounds of formula IV ##STR4## are reacted in a solvent in the presence of a catalyst with compounds of general formula V ##STR5## then the obtained compounds of formula I are transformed if desired by saponification, hydrolysis, salt formation, insertion of a protection group to another compound which belongs to the compounds of formula I, too. The pharmaceutical products of the invention can be used for the treatment of circulatory diseases, they inhibit the aggregation of blood plaques, dilate the bronchi and inhibit the secretion of gastric acid.

4-Oxo-PGI.sub.2 compounds, their use in inhibition of thrombii and their

New PGI.sub.2 derivatives and a process for their preparation are disclosed of the formula (I) ##STR1## wherein Q is hydrogen, a pharmacologically acceptable cation, or lower alkyl;

7-Oxo-PGI.sub.2 -derivatives and process for the preparation thereof and

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Budapest, Hungary

Jozsef Ivanics