Richter Gedeon Vegyeszeti Gyar Rt

Egyt Gyogyszervegyeszeti Gyar

Alkaloida Vegyeszeti Gyar

Biogal Gyogyszergyar

Jozsef Borsi

Erzsebet Mago Nee Karacsony

Istvan Elekes

Endre Csanyi

Ferenc Andrasi

Laszlo Tardos

Istvan Polgari

Lajos Wolf

Ildiko Kiraly

Katalin Pik

Gyula Horvath

Sandor Bajusz

Tamas Hamori

Lajos Toldy

Pal Berzsenyi

Endre Kasztreiner

Jeno Korosi

Laszlo Jaszlits

Sandor Elek

Gyorgy Cseh

Tibor Lang

Peter Botka

Gyorgy Rabloczky

Ilona Bodi

Geza Szilagyi

Andras Varro

Lajos Farkas

Eva Bozo

Tivadar Rettegi

Gyongyi Nagy Nee Csokas

ZSuzanne Lang Nee Rihmer

Katalin G Horvath

Zsuzsanna L Rihmer

Laszlo Czollner

The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiaz epi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. ##STR1## The new compounds of formula (I) can be prepared by reducing 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine of formula (II) with an inorganic or organic-inorganic and/or complex metal hydride and, if desired, separating the optically active forms of the compound of formula (I) thus-obtained and, if desired, converting the base or bases into acid addition salts or converting the salts into the free bases(s). ##STR2## The new compound of formula (I) possesses significant central nervous effects and can advantageously be used in the therapy.

1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-b

The invention relates to new substituted dihydropyridine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.6 are as defined herein after, the racemic and optically active variants as well as mixtures thereof, furthermore the acid addition salts of these compounds, pharmaceutical compositions containing the same and a process for the preparation thereof. The compounds of the general formula (I) can be advantageously applied for the treatment of pathologically severe hypertensions, their toxicity is low and they possess an advantageous therapeutic index.

Novel dihydropyridines having calcium antagonistic and antihypertensive

The invention relates to new 8.beta.-hydrazinomethyl-ergoline derivatives of the general formula (I), ##STR1## wherein x y stands for a ##STR2## or ##STR3## group, R stands for hydrogen or methyl group, and

Biologically active new 8.beta.-hydrazinomethyl-ergoline derivatives and

The invention relates to a novel compound of the formula ##STR1## and the pharmaceuticlly acceptable acid addition salts thereof, wherein R stands for a hydrogen atom or methyl group, x y designates a ##STR2## Q is a hydrogen atom or a benzyloxycarbonyl- or N-tert.-butyloxycarbonyl protective group, and R.sub.1 is the side chain of a natural .alpha.-amino acid selected from the group consisting of Arg--, Tryp-13 , Phe--, Ser--, Leu--, Val--, Meth--, Tyr--, His-- or Prol---side-chain. The compounds according to the invention possess antiserotonin and hypotensive effects and act upon the central nervous system.

Compounds of ergolene and ergoline structure and method for the

9,10-Dihydrolysergic acid-(3'-/pyrrolid-2'-on-1'-yl/-propyl)-amide, 1-methyl-9,10-dihydrolysergic acid-(thiazoline-2'-yl)-amide and lysergic acid-(3'-allyloxy-2'-oxy-propyl)-amide and their pharmaceutically acceptable acid addition salts possess antihypertensive and antiserotonin effect and exert an action on the central nervous system.

Novel lysergic acid amides and process for preparing same

New compounds of the formula ##STR1## wherein R is hydrogen or methyl group,

Compounds with ergoline skeleton

New compounds of the general formula (I) ##STR1## wherein R stands for hydrogen or methyl group, x y stands for a group of the formula ##STR2## and R.sub.1 stands for a group of the formula (III), (IV) or (V) ##STR3## wherein n is an integer from 4 to 10, ARE PREPARED BY ACYLATING A COMPOUND OF THE GENERAL FORMULA (II), ##STR4## wherein R and x y each have the same meanings as defined above, and R.sub.2 stands for a group of the formula (VI), (VII) or (VIII), ##STR5## with a C.sub.6-12 carboxylic acid or a C.sub.6-12 carboxylic acid halide. The new compounds of the general formula (I) and their acid addition salts can be used as antidepressants and antiserotonine agents with prolonged effects.

New acylated 2-aminothiazole derivatives of the general formula (I), ##SPC1## wherein

Acylated 2-aminothiazole derivatives

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Budapest, Hungary

Jozsef Borsi