Intervet International B.v.

Intervet Inc.

Merck Sharp + Dohme B.v.

Jozefus A C Smit

Hans Almer Middelbeek

Jacobus Johannes Adriana Maria Verheezen

The present invention pertains to a process for the preparation of a fast-disintegrating tablet () containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element () having formed therein at least one cavity, () cooling the solid element () to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity () to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet.

Process to form a tablet and apparatus suitable for applying this process

The present invention pertains to a process for the preparation of an orally disintegrating tablet for administration to a human subject, the tablet containing a medicinal substance to treat a disorder of the human subject, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element having formed therein at least one cavity, cooling the solid element to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity by extracting heat from the formulation through a cavity wall by conduction, to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity, and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to the tablet itself and a package comprising such a tablet.

Process to form an orally disintegrating tablet for human use

A method for fastening a thread () to a tampon (), in particular a veterinary tampon, comprising the steps of passing the thread through the tampon by means of a needle (), and knotting the loose ends of the thread, wherein that the step of passing the thread through the tampon comprises: -piercing the tampon () with two hollow needles (), -inserting the distal ends of the needles into a mould () that forms a passage () interconnecting the open ends of the hollow needles, feeding the thread () to the proximal end of one () of the two needles, -applying a suction pressure to the proximal end of the other () of the two needles, -opening the mould (), and -withdrawing the needles () from the tampon ().

Method and equipment for fastening a thread to a tampon

A tube weld seam test method and device for testing a tube weld seam () of a flexible tube () for leaks having: a first pinching device () and a second pinching device () for pinching closed the flexible tube () at a first position (A) and at a second position (B), the weld seam to be tested being arranged between the first and second positions (A; B); a compressing mechanism arranged for partly compressing a tube section enclosed between the first and second pinching devices (); and a pressure test device () arranged for testing an internal pressure of said tube section in order to test the tube weld seam for leaks.

Growing community of inventors

Boxmeer, Netherlands

Jozefus A C Smit