Arcus Biosciences, Inc.

Joyson J Karakunnel

Jay Patrick Powers

Manmohan Reddy Leleti

Juan Carlos Jaen

Jaroslaw Kalisiak

Kenneth Victor Lawson

Jenna Leigh Jeffrey

Lixia Jin

Methods of identifying compounds that modulate the conversion of AMP to adenosine by 5'-nucleotidase, ecto, and that possess particular pharmacokinetic characteristics are described herein. Methods of such compounds, and compositions comprising same, for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, are also provided.

Parenterally administered immune enhancing drugs

Provided herein are methods of treating a disease, disorder, or condition, mediated at least in part by the adenosine AN receptor (AR) and/or the adenosine Areceptor (AR) using Compound (I). In some embodiments, the disease or disorder is a cancer related disorder. Also provided herein are pharmaceutical compositions and single unit dosages of Compound (I). 

Dosing with an azolopyrimidine compound

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Potomac, MD, United States of America

Joyson J Karakunnel