Corning Incorporated

Joydeep Lahiri

Ye Fang

Po Ki Yuen

Norman Henry Fontaine

Florence Christine Monique Verrier

Dana Craig Bookbinder

Ann MeeJin Ferrie

Patrick David Tepesch

Cameron Wayne Tanner

Anthony Glenn Frutos

Brian L Webb

Yulong Hong

Peter J Kalal

Jeffrey Glenn Lynn

Steven J Jonas

Matthew John Dejneka

John Christopher Mauro

Santona Pal

Valerie Claudine Lacarriere

Jinlin Peng

Fang Lai

Srikanth Raghavan

Uwe Richard Muller

Alexander Mikhailovich Efremov

Jacques Gollier

Stephan Lvovich Logunov

Adam James Ellison

William James Miller

John Stephen Peanasky

Mark Alejandro Quesada

Raja Rao Wusirika

Anping Liu

Edward John Fewkes

Shawn Michael O'Malley

David M Root

Keith A Horn

Ellen Anne King

Alain R E Carre

Ying Zhang

Pronob Bardhan

Elizabeth Tran

Paul Ernest Gagnon, Jr

Florence Verrier

Hongming Wang

Guangshan Li

Melissann Marie Ashton-Patton

Mircea Despa

Michael Donavon Brady

Ronald Allen Faris

Terry T Goodrich

Alain Re Carre

Jin Liu

Wei Wang

James B Stamatoff

Jun Xi

Olivia Grace Weeks

Aspects of this disclosure pertain to a colorless material that includes a carrier, copper-containing particles, and either one or both of sodium thiocyanate and titanium dioxide. In one or more embodiments, the material exhibits, in the CIE L*a*b* system, an L* value in the range from about 91 to about 100, and a C* value of less than about 7, wherein C* equals &#x221a;(a*+b*). In some embodiments, the material exhibits a greater than 3 log reduction in a concentration of, under the EPA Test Method for Efficacy of Copper Alloy as a Sanitizer testing conditions.

Colorless copper-containing material

A substrate for use in fluorescent-detection methods is provided. The substrate includes at least one glass substrate portion, the at least one glass substrate portion including: between about 60 mol % to about 80 mol % SiO; between about 0 mol % to about 15 mol % AlO; between about 0 mol % to about 15 mol % BO; and about 2 mol % to about 50 mol % RO, wherein R is any one or more of Li, Na, K, Rb, Cs and x is 2, or wherein R is any one or more of Zn, Mg, Ca, Sr or Ba and x is 1.

Substrates for use in fluorescent-detection methods having glass substrate portion

Aspects of this disclosure pertain to a colorless material that includes a carrier, copper-containing particles, and quaternary ammonium. In one or more embodiments, the material exhibits, in the CIE L*a*b* system, an L* value in the range from about 91 to about 100, and a C* value of less than about 7, wherein C* equals &#x221a;(a*+b*). In some embodiments, the material exhibits a greater than 3 log reduction in a concentration of, under the EPA Test Method for Efficacy of Copper Alloy as a Sanitizer testing conditions.

Colorless material with improved antimicrobial performance

Cell culture compositions containing LFM-A13 or a structurally related compound can enhance global hepatic function. For example, LFM-A13 is shown to enhance levels of a broad variety of drug metabolism enzymes, including CYP enzymes, and other hepatic enzymes. LFM-A13 is also shown to promote differentiation of stem cells into hepatocytes. LFM-A13 and structurally related compounds can be used in cell culture to enhance global drug metabolism of liver cells for enhanced in vitro study the effects of drug metabolism on other candidate drug compounds.

Cell culture medium for enhanced hepatocyte function

Colorless copper and quaternary ammonium comprising material with antimicrobial performance

Embodiments of the present invention pertain to a material including a carrier and a co-biocide including copper ions and a biocide such as ZnPT, Tralopyril or a combination thereof. The material may include a copper-containing glass particles or cuprous oxide particles. In some embodiments, the copper-containing glass may include glass phase and a cuprite phase. In other embodiments, the copper-containing glass may include as plurality of Cuions, a degradable phase including BO, POand KO and a durable phase including SiO. In some embodiments, the carrier is a paint.

Antimicrobial materials exhibiting synergistic efficacy

Lighting units and light fixtures incorporating lighting units having light-diffusing optical fiber are disclosed. Lighting units include a light source, at least one light-diffusing optical fiber optically coupled to the light source, and a support plate. The at least one light-diffusing optical fiber scatters light that is optically coupled into the at least one light-diffusing optical fiber from the light source. The support plate has a retention groove to which a portion of the at least one light-diffusing optical fiber is coupled. The support plate also includes a perimeter. A groove length of the retention groove is greater than the perimeter of the support plate.

Lighting units having light-diffusing optical fiber

Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in high throughput methods and can be multiplexed.

Label free biosensors and cells

Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in highthough put methods and can be multiplexed.

The present invention overcomes the problems and disadvantages associated with prior art arrays by providing an array comprising a plurality of biological membrane microspots associated with a surface of a substrate that can be produced, used and stored, not in an aqueous environment, but in an environment exposed to air under ambient or controlled humidities. Preferably, the biological membrane microspots comprise a membrane bound protein. Most preferably, the membrane bound protein is a G-protein coupled receptor, an ion channel, a receptor serine/threonine kinase or a receptor tyrosine kinase.

Arrays of biological membranes and methods and use thereof

A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

Method for depth resolved sensing of biological entities based on surface plasmon resonance sensors

The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells.

System and method for performing G protein coupled receptor (GPCR) cell assays using waveguide-grating sensors

The invention relates to G protein-coupled receptor (GPCR) microarrays on porous substrates for structural or functional analyses of GPCRs, and methods of preparing porous substrate surfaces for receiving membranes that comprise GPCRs. In one embodiment, a GPCR microarray of the invention comprises a membrane adhered to an upper surface of a porous substrate, the membrane spanning across a plurality of pores on the porous substrate to form a plurality of cavities having sufficient geometry to permit entry of assay reagents into each cavity, thereby allowing access of assay reagents to both sides of GPCR in the membrane.

Membrane arrays and methods of manufacture

Growing community of inventors

Painted Post, NY, United States of America

Joydeep Lahiri