Genmab A+s

Joyce Meesters

Paul Parren

Janine Schuurman

Aran Frank Labrijn

Joost J Neijssen

Edward Norbert Van Den Brink

Bart De Goeij

Jan Van De Winkel

Patrick Van Berkel

Ewald T J Van Den Bremer

David Satijn

Ole Baadsgaard

Tom Vink

Rene Hoet

Thilo Riedl

Simone De Haij

Rik Rademaker

Arnout F Gerritsen

Isil Altintas

Michael J Gramer

Amitava Kundu

Muriel Van Kampen

Patrick Priem

Werner L Vos

Mark Chiu

Thomas C Nesspor

Adam Zwolak

Anthony A Armstrong

Matthew Bunce

Edward N Brink

Ewald Van Bremer

René Hoet

Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.

Heterodimeric antibody Fc-containing proteins and methods for production thereof

The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.

Humanized or chimeric CD3 antibodies

Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.

Bispecific antibodies against HER2 and CD3

The present invention relates to an in vitro method for production of heterodimeric proteins.

Production of heterodimeric proteins

Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.

Inert format

Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

Monoclonal antibodies against HER2

Novel rodent bispecific heterodimeric proteins, such as rodent bispecific antibodies, in vitro method for producing such, and uses thereof.

Rodent bispecific heterodimeric proteins

Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related anti-body-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

Heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.

Growing community of inventors

Utrecht, Netherlands

Joyce Meesters