Circuit Therapeutics, Inc.

Mgi Tech Co., Ltd.

Joyce Huang

Dan E Andersen

David F Moore

Scott Delp

Alexander K Arrow

Greg Stahler

Ananya Mitra

David Moore

Paul Lundquist

Jay Shafto

Ziyi Wu

Frederic Moll

Embodiments of the disclosure include methods and systems for nucleic acid sequencing that may include an objective coupled to an actuator, wherein the actuator is configured to move the objective over a surface of a substrate. In some embodiments, a droplet may be disposed on the surface of the substrate, and the droplet may be moved along with the objective. The distal end of the objective may include a material that provides a higher friction against the droplet than a material of the surface of the substrate. In some embodiments, the distal end of the objective may be immersed in a fluid as it is moved over the surface of the substrate. The substrate may include vertical walls within a region to retain the fluid.

Systems and methods for optical scanning and imaging through a fluid medium for nucleic acid sequencing

Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.

System and method for optogenetic therapy

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Redwood City, CA, United States of America

Joyce Huang