Harvard College

The General Hospital Corporation

Dana-farber-cancer Institute Inc.

Centre Hospitalier Universitaire Vaudois

Joy Luz Nishikawa

Gerhard Wagner

Haribabu Arthanari

Sara Jean Buhrlage

Anders M Naar

Anders Näär

Andras Pal Boeszoermenyi

Dominique Sanglard

Provided herein are compounds (e.g., compounds of Formulae (I), (II), and (III)) which are anti-fungal agents and can be used in the treatment of diseases, including infectious diseases. The invention provides methods of treating diseases in a subject (e.g., infectious diseases such as fungal infections), and methods of killing or inhibiting the growth of fungi in or on a subject or biological sample. The compounds may be used in subjects, in clinical settings, or in agricultural settings. 

Antifungal compounds and uses thereof

The present invention relates to the identification of molecular mechanisms associated with multidrug resistance (MDR) in fungal infections. More specifically, fungi harbor a nuclear receptor-like pathway controlling MDR, which represents a novel therapeutic target for the treatment of MDR in pathogenic fungi such as

High throughput screens for small-molecule inhibitors of the nuclear receptor-like pathway regulating multidrug resistance in fungi

Growing community of inventors

Cambridge, MA, United States of America

Joy Luz Nishikawa