The Medical College of Wisconsin, Inc.

Mcw Research Foundation, Inc.

Colby Pharmaceutical Company

Iowa State University Research Foundation Inc

Joy Joseph

Balaraman Kalyanaraman

David A Zarling

Anumantha G Kanthasamy

Hirak S Basu

Micael J Hardy

Marcos Lopez

Kathleen M Schmainda

Douglas Edward Prah

Apocynin derivative compounds, active pharmaceutical ingredients, dosage forms, and methods of use thereof as neuroprotectants in the brain of mammals.

Neuroprotective compounds and their use

The inventions disclosed include methods of treating cancers and related neoplasias, especially prostate cancer, with pharmaceutically acceptable salts comprising lipophilic cation moieties linked to nitroxide or linked to hydroxylamine anti-oxidant groups.

Mitochondria targeted cationic anti-oxidant compounds for prevention, therapy or treatment of hyper-proliferative disease, neoplasias and cancers

A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.

In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging

Growing community of inventors

New Berlin, WI, United States of America

Joy Joseph