Codexis, Inc.

Novartis Ag

Jovana Nazor

Oscar Alvizo

Derek J Smith

Jeffrey C Moore

Steven James Collier

Scott J Novick

Gjalt W Huisman

Nicholas John Agard

Jacob M Janey

Wan Lin Yeo

Joly Sukumaran

Haibin Chen

Gregory Hughes

Stefanie Ng Minor

Gregory Allan Cope

Vesna Mitchell

Jonathan Vroom

Agustina Rodriguez-Granillo

Nikki Dellas

Da Duan

Nicholas M Marshall

Shiwei Song

Deeptak Verma

Xiyun Zhang

Mark A Huffman

Iman Farasat

Jack S Liang

Ravi David Garcia

Anna Fryszkowska

Keith Allen Canada

David Elgart

Michael A Crowe

Grant S Murphy

Nandhitha Subramanian

Harvinder Chagger Maniar

Santhosh Sivaramakrishnan

Rama Voladri

Birgit Kosjek

Ellen D Eberhard

Martina Quintanar-Audelo

Christopher Michael Micklitsch

Jay Russell

Cuixia Wang

Benjamin Mijts

Robert Osborne

Yong Koy Bong

Michael D Clay

David Entwistle

James Nicholas Riggins

Robert Kevin Orr

Michael Vogel

Katrina W Lexa

Auric Anthony Sowell-Kantz

Judy Victoria Antonio Viduya

Shane Grosser

Matthew Truppo

Mikayla Jianghongxia Krawczyk

Jun Zhu

Ericka Bermudez

Mathew G Miller

Xiang Yi

Courtney Dianne Moffett

Margie Tabuga Borra-Garske

Jonathan S Penfield

Joshua N Kolev

Hao Yang

Dewan Andrews

Donald Scott Baskerville

Derek Smith

Sandy M Gomes

Jian Ding

Fernando Valle

Jie Yang

Paul N Devine

Louis Clark

Goutami Banerjee

Thomas Ruch

Stephan Jenne

Erika M Milczek

Claus M Krebber

Aksiniya Lyubenova Petkova

Yunzhong Li

Dominique Grimler

Kurt Laumen

Kristian Karlshoej

Michael Foulkes

Ernst Kuesters

Kaman Chan

Yoram Barak

Kenneth W Mitchell

Nikki D Kruse

Alberto Ortega Guerra

Michael Crowe

Giancarlo Francese

Changxue Lin

Shangjun Teng

Chihui An

Steven Miller

The present invention provides engineered transaminase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered transaminase polypeptides. Methods for producing transaminase enzymes are also provided. In some embodiments, the engineered transaminase polypeptides are optimized to provide improved enzyme properties under minimal aqueous conditions in wet organic solvents.

Engineered transaminase polypeptides

The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.

Engineered galactose oxidase variant enzymes

The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.

Engineered deoxyribose-phosphate aldolases

The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Engineered phosphopentomutase variant enzymes

The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Polynucleotides encoding engineered imine reductases

The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.

Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs

The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.

Engineered transaminase polypeptides for industrial biocatalysis

The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Engineered proline hydroxylase biocatalysts for hydroxylation of chemical compounds

The present invention provides engineered acetate kinase (AcK) enzymes, polypeptides having AcK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing AcK enzymes are also provided. The present invention further provides compositions comprising the AcK enzymes and methods of using the engineered AcK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Engineered acetate kinase variant enzymes

The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

Ketoreductase polypeptides and polynucleotides

The present disclosure relates to engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The present disclosure also provides methods of using the engineered DNA polymerase polypeptides or compositions thereof for diagnostic and other purposes.

Engineered DNA polymerase variants

The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Engineered purine nucleoside phosphorylase variant enzymes

The present invention provides engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The invention also provides methods for use of the compositions comprising the engineered DNA polymerase polypeptides for diagnostic and other purposes.

The present invention provides engineered peroxidase enzymes, polypeptides having peroxidase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing peroxidase enzymes are also provided. The present invention further provides compositions comprising the peroxidase enzymes and methods of using the engineered peroxidase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.

Peroxidase activity towards 10-acetyl-3,7-dihydroxyphenoxazine

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Milpitas, CA, United States of America

Jovana Nazor