Thomas Jefferson University

Jouni J Uitto

Eric F Bernstein

Elaine M Tan

In vivo and in vitro model of cutaneous photoaging

A transgenic mouse capable of expressing human elastin promoter is provided. Mouse fibroblast cultures derived from this transgenic mouse are also provided. In addition methods of identifying compounds capable of inhibiting cutaneous photodamage with this transgenic mouse or fibroblast cultures derived from these mice are provided.

A composition for the treatment of skin fibrotic and other cirrhotic diseases comprising an endothelial cell growth factor, either alone or in combination with heparin or a heparin-like compound is provided. Methods for the treatment of skin fibrotic and other cirrhotic diseases and for inhibition of collagen synthesis by skin fibroblasts using an endothelial cell growth factor either alone or in combination with heparin or a heparin-like compound are also provided.

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Gladwyne, PA, United States of America

Jouni J Uitto