Legochem Biosciences, Inc.

Neopharm Co., Ltd.

Joung Yul Yun

Sung Ho Woo

Hyang Sook Lee

Tae Kyo Park

Yong Zu Kim

Chul Soon Park

Sang Eun Chae

Young Lag Cho

Kyu Man Oh

Hyun Jin Kwon

Dae Hyuck Kang

Young Jae Yang

Hye Jin Heo

Se Kyoo Jeong

Dae Yon Lee

Byeong Deog Park

Hye Jin Kang

Jeong Eun Jeon

Kyuman Oh

Hyung Mook Choi

Hyung Sub Gwak

Young Zu Kim

Uk Il Kim

The present invention relates to novel cephalosporin derivatives represented by X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

Cephalosporin derivatives and pharmaceutical compositions thereof

Provided are heterocyclic compounds, having effects of treating and preventing inflammatory diseases and treating skin wounds, and particularly, exhibiting effects of recovering disrupted skin barriers, mitigating inflammation, and pruritus. Also, a composition containing the compound as an effective component can be used to mitigate various inflammatory diseases and protease activated receptor-2 (PAR-2)-overexpressed diseases, and can be particularly used as a composition having an anti-inflammatory function in inflammatory skin diseases including atopic dermatitis and the like, by inhibiting PAR-2 activity.

Heterocyclic compound, and composition for treating inflammatory diseases using same

The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R, and Rare as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. Compounds of the present invention are effective ingredients for the broad spectrum of antibiotic resistance, exhibit low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

Growing community of inventors

Deajeon, South Korea

Joung Yul Yun