Wellstat Biologics Corporation

Jouhn-Wern Jang

Jeffrey Allan Miller

Tzer-Fen Chen

Envelope viruses (e.g. Newcastle disease virus (NDV)) are formulated for storage at moderately cold temperatures (e.g. &#x2212;20&#xb0; C.). The formulation is an aqueous solution containing the enveloped virus at a concentration of from 10PFU/mL to 10PFU/mL; and a non-reducing saccharide (e.g. sucrose). When the non-reducing saccharide is a disaccharide it is present in the solution at a concentration of from 5% (w/v) to 50% (w/v), and when it is a monosaccharide it is present in the solution at a concentration of from 2.5% (w/v) to 25% (w/v). The solution has an osmotic pressure of about 250 mOs or higher, and has a pH of from 5 to 10.

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Jouhn-Wern Jang