Universitat De Valéncia, Estudi General

Elysium Health, Inc.

Fundacion Universidad Catolica De Valencia San Vicente Martir

FundaciÓ InvestigaciÓ Hospital General Universitari De ValÈncia Per A La InvestigaciÓ BiomÈdica I CiÈncies De La Salut

Idcq Hospitales Y Sanidad, S.l.u.

José María Estrela Arigüel

Ryan Dellinger

María Benlloch García

Rosario Salvador Palmer

María Lucía Rodríguez Romero

Concepción Cerdá Micó

José Alfredo Pellicer Artés

Lilian Soraya Vallés Martín

Guillermo María Sáez Tormo

Joan Antoni Sirerol Talens

Rosario Salvador

Maria Elena Obrador Pla

María Elena Plá Obrador

Javier Luis Alcácer García

Provided herein are methods and compositions related to treating motor neuron diseases, such as ALS, in a subject by administering to the subject (e.g., orally administering to the subject) a composition comprising nicotinamide riboside, pterostilbene and a phosphodiesterase (PDE) inhibitor, including a PDE4 inhibitor such as ibudilast, and also including a thiol/cysteine donor, such as acetylcysteine.

Methods and compositions for treating motor neuron diseases

The present invention relates to a combination comprising pterostilbeneor pterostilbene phosphate or a pharmaceutically acceptable salt thereof, a glutathione depleting agent and a cancer chemotherapeutic agent. The invention also relates to the medical use of this combination, in particular for the treatment and/or prevention of cancer.

Combination comprising pterostilbene for the treatment of cancer

Growing community of inventors

Valencia, Spain

José María Estrela Arigüel