Medlumics S.l.

José Luis Rubio Guivernau

Eduardo Margallo Balbás

Juan Sancho Durá

Juan Lloret Soler

Kirill Zinoviev

Santiago Jiménez Valero

Alejandro Barriga Rivera

Matthieu Duperron

Justo Contreras Bermejo

Sara María Más Gómez

Alberto Martin

William Kennedy Landles

Andrés Cifuentes

Blair Ungar

Jorge H Jimenez

James L Greene

Embodiments for crossing an occlusion by controlling a guide with the aid of optical coherence tomography (OCT) data are described. Embodiments include transmitting one or more beams of radiation via one or more waveguides on a flexible substrate within a guide wire. One or more beams of scattered or reflected radiation may be received from a sample via one or more waveguides. Depth-resolved optical data of the sample may be generated based on the received beams of scattered or reflected radiation. The depth-resolved data may be used for determining at least one of a distance between the guide wire and a wall of the artery and a distance between the guide wire and an occlusion within the artery. A position of the guide wire within the artery may then be controlled based on the determined distance or distances.

Crossing coronary occlusions

A medical instrument is described that includes an optical source, an optical fiber, and a waveguide patterned upon a substrate. The optical fiber receives radiation from the optical source and includes a first segment and a second segment. The second segment is rotated about an optical axis relative to the first segment. The waveguide receives radiation from the optical source and guides a beam of radiation. The waveguide includes a first waveguide segment designed to impart a first differential group delay on the beam of radiation and a second waveguide segment designed to impart a second differential group delay on the beam of radiation. A sum of the first differential group delay and the second differential group delay is substantially zero.

Bi-refringence compensated waveguides

A fabrication method includes arranging a plurality of dice on a substrate and performing a first etching process that etches a first layer of the substrate at a boundary between adjacent dice on the substrate. The etching forms facets of one or more waveguides that are defined within the first layer, and the etching leaves a portion of the first layer in the boundary between the adjacent dice. The method continues with a second etching process that etches the portion of the first layer and a second layer beneath the portion of the first layer, the second etching process forming a trench in the boundary where the second layer has a different material than the first layer. The method also includes separating the dice from one another along the trench.

Techniques for fabricating waveguide facets and die separation

Systems and methods for performing RF ablation while monitoring the procedure using low coherence interferometry (LCI) data are described. A catheter includes a distal section, a proximal section, a multiplexer, and a sheath coupled between the distal section and the proximal section. The distal section includes one or more electrodes configured to apply RF energy to a portion of a sample in contact with the electrode. The distal section also includes a plurality of optical elements configured to transmit one or more beams of exposure radiation away from the distal section of the catheter. The proximal section includes an optical source configured to generate a source beam of radiation and a detector configured to generate depth-resolved optical data. The multiplexer is configured to generate the one or more beams of exposure radiation from the source beam of radiation.

Radiofrequency ablation catheter with optical tissue evaluation

Systems and methods for controlling a guide with the aid of optical coherence tomography (OCT) data are described. A guide wire includes at least one optical fiber, a flexible substrate, and one or more optical elements. The at least one optical fiber transmits a source beam of radiation. The flexible substrate includes a plurality of waveguides. At least one of the plurality of waveguides transmits one or more beams of radiation away from the guide wire, and at least one of the plurality of waveguides receives one or more beams of scattered radiation that have been reflected or scattered from a sample. The multiplexer generates the one or more beams of exposure radiation from the source beam of radiation. The one or more optical elements at least one of focus and steer the one or more beams of radiation.

Optical coherence tomography probe for crossing coronary occlusions

Systems and methods for performing RF ablation while monitoring the procedure using low coherence interferometry (LCI) data are described. A catheter includes a distal section, a proximal section, a multiplexer, and a sheath coupled between the distal section and the proximal section. The distal section includes several interconnected optical ports configured to transmit exposure radiation toward a sample and receive radiation that have been reflected or scattered from the sample. The interconnected optical ports are formed on a substrate having rigid sections and flexible sections arranged around the distal section. A holder maintains the interconnected optical elements in a fixed spatial relationship.

A Time Domain Optical Coherence Tomography system using a modulation scheme multiplexes the scanning range of the delay line into different spectral bands. Such a modulation scheme may allow for power consumption reduction compared with a single delay line element since the same modulation pattern is being used for several channels. In an example, the optical coherence tomography system may include a plurality of stages, each stage having a group delay element. The distinct group delays may be introduced to scan a sample with distinct electrical frequency bands at distinct axial scanning depth ranges.

Distributed delay-line for low-coherence interferometry

A chip package includes a housing, one or more electrical connections coupled to an exterior of the housing, a photonic integrated circuit, and a scanning unit. Both the photonic integrated circuit and the scanning unit are disposed within the housing. The photonic integrated circuit has at least one waveguide designed to guide a beam of light. The scanning unit is designed to laterally scan the beam of light across a focal plane outside of the housing. The scanning unit is aligned with the photonic integrated circuit such that the beam of light is coupled between the photonic integrated circuit and the scanning unit.

Miniaturized OCT package and assembly thereof

A system for optical coherence tomography using multiple interferometers presented. The interferometry system includes a source configured to generate a variable wavelength light beam. A first splitter is configured to split the variable wavelength light beam to at least a first light beam and a second light beam. A first delay element is configured to delay the first light beam by a first time delay. A second delay element is configured to delay the second light beam by a second time delay, such that the delayed first light beam and the delayed second light beam are out of coherence with each other. A first interferometer is configured to receive the delayed first light beam as an input. A second interferometer is configured to receive the delayed second light beam as an input.

High-speed optical coherence tomography using multiple interferometers with suppressed multiple scattering cross-talk

A device and a method for manufacturing the device are presented. The device includes a ridge, a peninsula formation, and a conductive trace. The ridge is defined within a semiconducting material. The peninsula formation is also defined within the semiconducting material and is adjacent to the ridge such that a gap exists between an end face of the peninsula formation and a side wall of the ridge. The conductive trace bridges across the gap such that the conductive trace runs over a top surface of the peninsula and a top surface of the ridge.

Structure for optical waveguide and contact wire intersection

A photonic integrated circuit is presented that includes a substrate, and a first and second waveguide patterned on the substrate. The first waveguide guides an input beam of radiation. The photonic integrated circuit also includes a coupling region, wherein the first and second waveguides each pass through the coupling region. One or more modulating elements are coupled to each of the first and second waveguides. The first waveguide and the second waveguide have a first facet and a second facet, respectively, and first and second reflections are generated at the first and second facets within the first and second waveguides, respectively. The one or more modulating elements coupled to each of the first and second waveguides are designed to adjust the phase of the first and second reflections before the first and second reflections pass through the coupling region.

Bidirectional photonic integrated circuit with suppressed reflection

A scanning device is presented having a substrate with a first surface and an opposite, parallel second surface. A region of the substrate includes the first surface and the opposite parallel second surface, and is defined via an etching process through a thickness of the substrate, where the region remains attached to the substrate via one or more hinges. A waveguide is patterned over the first surface of the region and guides a beam of radiation along a length of the waveguide. The scanning device includes a facet located on the first surface of the region. The facet is designed to reflect at least a portion of the beam of radiation through the region. An optical element is located on the second surface of the region, and is designed to receive the reflected portion of the beam of radiation.

Optical beam scanner

A system includes a waveguide that guides a beam of radiation, a variable delay unit, and a polarization-dependent modulating unit. The variable delay unit modulates the refractive index in a region, and the waveguide makes a plurality of passes through the region. The polarization-dependent element compensates for birefringence associated with the beam of radiation and includes a polarization splitter and a plurality of modulating elements. The polarization splitter has a first arm and a second arm that each include modulation segments. The beam of radiation is split between the first arm and the second arm and recombined after traversing the modulation segments. The recombination of the beam generates a first polarized beam of radiation and a second polarized beam of radiation. The plurality of modulating elements apply a first and second modulation to the first polarized beam of radiation and the second polarized beam of radiation respectively.

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Madrid, Spain

José Luis Rubio Guivernau