Abm Technologies, LLC

José Luis Fernández García

Germán Bou Arévalo

Maria Tamayo Novas

Rebeca Santiso Brandariz

Jaime Gosálvez Berenguer

Fátima María Otero Fariña

Fatima Maria Otero Farina

María Tamayo Novás

A method of rapidly evaluating the susceptibility of a strain of bacteria to a cell wall synthesis inhibiting antibiotic based on an assessment of cell enlargement in response to doses of the cell wall synthesis inhibiting antibiotic which are correlated to breakpoints of bacterial susceptibility.

Method for the rapid determination of susceptibility or resistance of bacteria to antibiotics

The present invention relates to a method for the rapid evaluation of bacterial susceptibility or non-susceptibility of bacteria to antibiotics that inhibit protein synthesis. The rationale is to identify bacterial responses that depend or are influenced by protein synthesis. If this response is prevented or reduced by the antibiotic that inhibits the protein synthesis, the bacteria are susceptible to this antibiotic. Otherwise, if the response keeps similar despite the incubation with the antibiotic, the bacteria are not susceptible or resistant to this antibiotic. These responses could be determined at the DNA lev-el, cell wall level, morphological level or any other experimental approach, including metabolic, bio-chemical, physiological or genetic processes.

Procedure for the rapid determination of bacterial susceptibility to antibiotics that inhibit protein synthesis

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Oleiros, Spain

José Luis Fernández García