Proyecto De Biomedicina Cima, S.l.

Josune Orbe Lopategui

José Antonio Páramo Fernández

Rosario Serrano Vargas

Julen Oyarzabal Santamarina

José Antonio Rodriguez Garcia

Jose Antonio Rodriguez Garcia

Jose Antonio Paramo Fernandez

Jóse Antonio Rodríguez García

José Antonio RODRÍGUEZ GARCÍA

José Antonio Rodríguez García

It relates to spirocyclic compounds of formula (I), or pharmaceutically or veterinary acceptable salts thereof, or any stereoisomers either of the compounds of formula (I) or of their pharmaceutically or veterinary acceptable salts, wherein A and B form a spirocyclic ring system wherein the spiro atom connecting A and B is a carbon atom and wherein A is a known 3- to 8-membered carbocyclic or heterocyclic monocyclic ring or a known 6- to 18-membered carbocyclic or heterocyclic polycyclic ring system; B is a known 4- to 7-membered carbocyclic or heterocyclic monocyclic ring; C is phenyl or a known 5- to 6-membered heteroaromatic ring; and R-Rare as defined herein. It also relates to a process for their preparation, as well as to the intermediates used in this process; to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular as antifibrinolytic and antihemorragic agents. 

Antifibrinolytic compounds

The present invention relates to the use of matrix metalloproteinase MMP-10 in the preparation of a pharmaceutical composition useful for thrombolytic therapy, it also being possible for said composition to contain a plasminogen activator. Additionally, the present invention relates to said pharmaceutical composition for the treatment of thrombotic disorders.

Use of matrix metalloproteinase-10 (MMP-10) for thrombolytic treatments

The present invention concerns the use of a neutralizing antibody for matrix metalloproteinase-10 (MMP-10) in the preparation of a medicine useful for anti-fibrinolytic treatment, and for hemorrhages and hemorrhagic complications of various etiologies.

Methods for anti-fibrinolytic treatment using MMP-10 neutralizing antibody

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Pamplona, Spain

Josune Orbe Lopategui