Actinium Pharmaceuticals, Limited

Actinium Pharmaceueuticals, Inc.

Josue Manuel Moreno Bermudez

Jaime Simon

Michael Schilp

Mark Harfensteller

Oliver Buck

Richard Henkelmann

Eva Kabai

Andreas Turler

Ernst Huenges

Andreas Türler

A Gaylord King

Andreas Tuerler

Ernst Hueenges

Mauritius W Geerlings

Ernst Hüenges

The present invention describes a method for purification ofAc from irradiatedRa-targets provided on a support comprising a leaching treatment of theRa-targets for leaching essentially for the entirety ofAc andRa with nitric or hydrochloric acid, followed by a first extraction chromatography for separatingAc fromRa and other Ra-isotops and a second extraction chromotography for separatingAc fromPo andPb. The finally purifiedAc can be used to prepare compositions useful for pharmaceutical purposes.

Method for purification of 225AC from irradiated 226RA-targets

Methods for generating an Ac-225 radioconjugate comprising a monoclonal antibody (mAb) (IgG) is disclosed. The Ac-225 radioimmunoconjugate is an [Ac-225]-p-SCN-Bn-DOT AIHuM195 radioimmunoconjugate.

Methods for generating radioimmunoconjugates

The present invention describes a method for purification ofAc from irradiatedRa-targets provided on a support, comprising a leaching treatment of theRa-targets for leaching essentially the entirety ofAc andRa with nitric or hydrochloric acid, followed by a first extraction chromatography for separatingAc fromRa and other Ra-isotops and a second extraction chromatography for separatingAc fromPo andPb. The finally purifiedAc can be used to prepare compositions useful for pharmaceutical purposes.

The invention is directed to a method for the purification of Radium, in particularRa, for target preparation for an essentially pureAc production from available radioactive sources, using an extraction chromatography in order to separate chemically similar elements such as Ba, Sr, and Pb from the desired Ra; wherein said extraction chromatography has an extractant system on the basis of a crown ether. The invention is related to a method for recycling ofRa, for target preparation forAc production from radium sources irradiated with accelerated protons (p,2n), after separation of the producedAc. In this method a combination of the above extraction chromatography and a cation exchange chromatography is used. The obtainedRa is essentially free of the following chemical contaminants consisting of Ag, Al, As, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, K, Li, Mg, Mn, Na, Ni, Pb, Sr, V, Zn, and Ba.

Method for the purification of radium from different sources

The present invention refers to a method for producing a radium target for the production of radionuclides by means of accelerated protons, whereby at least one radium containing material out of an aqueous-organic solution or suspension of such a material is applied by means of a dispersing device on a surface in such a way that the dispersing device and the surface are moving relatively towards each other and that the solvent is removed substantially spontaneously. Further, the invention refers to a radium target that is created in such a way that it may exhibit an activity of up to 1.5 curie. The radium targets according to the present invention serve for the production of the radionuclideAc, which may be used in nuclear medicine in the treatment of cancer, particularly in form of its daughter nuclideBi.

Radium target and method for producing it

The present application is directed to a method for the purification of Radium, in particularRa, for target preparation for an essentially pureAc production from available radioactive sources, using an extraction chromatography in order to separate chemically similar elements such as Ba, Sr, and Pb from the desired Ra; wherein said extraction chromatography has an extractant system on the basis of a crown ether. The invention is further related to a method for recycling ofRa, for target preparation forAc production from radium sources irradiated with accelerated protons (p,2n), after separation of the producedAC. In this method a combination of the above extraction chromatography and a cation exchange chromatography is used. The obtainedRa is essentially free of the following chemical contaminants consisting of Ag, Al, As, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, K, Li, Mg, Mn, Na, Ni, Pb, Sr, V, Zn, and Ba.

Growing community of inventors

Ismaning, Germany

Josue Manuel Moreno Bermudez