Duke University

Immunolight, LLC

Immunoloight, Llc.

Joshua T Stecher

Frederic Avery Bourke, Jr

Michael J Therien

Ian Nicholas Stanton

Jennifer Ann Ayres

Harold Walder

Tuan Vo-Dinh

Joseph H Simmons

Benoit Lauly

Molly K Gregas

Zak Fathi

Zhenyuan Zhang

Jonathan P Scaffidi

Stephen John Norton

Yan Zhang

Venkata Gopal Reddy Chada

Zakaryae Fathi

Eric John Toone

James Clayton

Diane Renee Fels

Mark DeWhirst

Joseph A Herbert

Katherine Sarah Hansen

Dave Gooden

Frederic A Bourke

Jennifer Ayres

Zakarayae Fathi

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength &#x3bb;, to generate a second wavelength &#x3bb;of radiation having a higher energy than the first wavelength &#x3bb;. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Non-invasive energy upconversion methods and systems for in-situ photobiomodulation

Non-invasive energy upconversion methods and systems

System for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The system can be used in methods which can be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure.

A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

Adhesive bonding composition and method of use

A nanoparticle-based system for enhancement of emitted light inside a medium. The nanoparticle-based system includes a phosphorescent material which, upon activation, produces the emitted light, and a metallic structure attached to the phosphorescent material. The metallic structure has a surface plasmon resonance which resonates at a frequency which spectrally overlaps with one or more frequencies of the emitted light.

Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength &#x3bb;, to generate a second wavelength &#x3bb;of radiation having a higher energy than the first wavelength &#x3bb;. The methods may further be performed by application of an initiation energy to activate a photoactivatable agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure.

A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength &#x3bb;of radiation, to generate a second wavelength &#x3bb;of radiation having a higher energy than the first wavelength &#x3bb;and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength &#x3bb;or the second wavelength &#x3bb;, or with both &#x3bb;and &#x3bb;. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength &#x3bb;, generates the photostimulated reaction.

Up and down conversion systems for production of emitted light from various energy sources

Growing community of inventors

Durham, NC, United States of America

Joshua T Stecher