Blueprint Medicines Corporation

Joshua T Close

Jason D Brubaker

Chandrasekhar V Miduturu

Thomas A Dineen

Joseph L Kim

Michael J Burke

One embodiment of the disclosure is a compound represented by Formula I or a pharmaceutically acceptable salt thereof. The variables in Formula I are defined herein. Compounds of Formula I are MAP4K1 inhibitors, which can be used to treat a diseases or disorders in a subject that benefits from control of MAP4K1 activity.

MAP4K1 inhibitors

One embodiment of the disclosure is a compound represented by Formula I or a pharmaceutically acceptable salt thereof. The variables in Formula I are defined herein. Compounds of Formula I are selective MAP4K1 inhibitors, which can be used to treat a diseases or disorders in a subject that benefits from control of MAP4K1 activity.

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Cambridge, MA, United States of America

Joshua T Close