University of Arkansas

Kagawa University

The Kitasato Institute

Ochsner Clinic Foundation

Montefiore Medical Center

Okayama University

National University Corporation Kagawa Univesity

Joshua Sakon

Osamu Matsushita

Robert C Gensure

Tulasi Ponnapakkam

Takaki Koide

Sagaya Theresa Leena Philominathan

Ranjitha Katikaneni

Nozomu Nishi

Robert Beitle

Sagaya Theresa Philominathan

Keisuke Tanaka

Suresh Kumar Thallapuranam

David S McNabb

Kevin Raney

Jin-Woo Kim

Craig E Cameron

Kentaro Uchida

Bhuvanesh Dave

Jeff Zhiqiang Lu

Samuel G Mackintosh

Thomas A Jennings

Ryan Bauer

Jeffrey Roeser

Katarzyna Janowska

Stephanie Beitle

Rudra Palash Mukherjee

Hazim Aljewari

Joseph Batta-Mpouma

Robert Gensure

Theresa Leena Philominathan Sagaya

Osama Matsushita

The present invention provides collagen-binding agents that can be used to treat wounds, ischemic heart disease, and other conditions. The collagen-binding agents comprise a therapeutic agent, a protease cleavage site, and a collagen-binding domain. The present invention further provides pharmaceutical compositions and biomedical devices comprising the disclosed collagen-binding agents, as well as methods for treating a condition using the collagen-binding agents.

Release of growth factors at wound healing stages

This invention relates generally to covalently crosslinked colloidal cellulose nanocrystals (xCNC) and methods of preparation and use thereof. The colloidal cellulose nanocrystals (CNCs) are covalently crosslinked in aqueous suspension to generate a network showing tunable physicochemical properties. The xCNC structures are tunable in terms of their physicochemical properties and arrangement within the hydrogel network. The covalent crosslinking of solitary sulfonated (—OSO) CNCs can be accomplished without prior hydroxyl replacement or functionalization.

Crosslinked colloidal cellulose nanocrystals and methods of preparation and use thereof

The invention generally relates to collagen-binding agent compositions and methods of using the same. More specifically, the invention relates in part to new collagen-binding agent compositions and methods that may be used to treat damaged collagen within tissues or used to specifically target therapeutics to tissues containing undamaged or damaged collagen.

Collagen-binding agent compositions and methods of using the same

Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

Delivery of therapeutic agents by a collagen binding protein

Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.

Fusion proteins of collagen-binding domain and parathyroid hormone

Photoluminescent proteins resistant to protein cleavage reagents are described herein. In being resistant to cleavage reagents, such photoluminesncent proteins can reduce the number of digestion or cleavage products, thereby simplifying quantification and purification of recombinant protein compositions. In some embodiments, a photoluminescent protein described herein comprises an amino acid sequence having an absence of internal methionine residues.

Cleavage resistant photoluminescent proteins and applications thereof

Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

Growing community of inventors

Fayetteville, AR, United States of America

Joshua Sakon