The Invention Science Fund I LLC

Gearbox LLC

Searete LLC

Joshua L Dowling

Lowell L Wood, Jr

Roderick A Hyde

Nathan P Myhrvold

Muriel Y Ishikawa

Eric Leuthardt

Victoria Y H Wood

Ralph G Dacey, Jr

Jordin T Kare

Gregory J Della Rocca

Gregory Zipfel

Colin Derdeyn

Eleanor V Goodall

Michael A Smith

Clarence T Tegreene

Edward Stuart Boyden

Elizabeth A Sweeney

Paul Santiago

Todd J Stewart

Stephen L Malaska

Dennis James Rivet, Ii

Eric C Leuthardt

Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

Method and system for modulating neural activity

Methods and related systems for modulating neural activity by cyclically modulating neural activity in peripheral neural structures are disclosed. Neural activity may be modulated cyclically by stimuli delivered via various types of stimulus sources. In an aspect, activity of a sensory nerve is modulated. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain, or an immune or inflammatory response or process. Delivery of stimuli for modulating neural activity may be controlled in part in response to an input from a user input device.

Methods and related systems for modulating neural activity by cyclical blocking of conduction in peripheral neural structures are disclosed. Neural activity may blocked cyclically by blocking stimuli delivered via various types of blocking stimulus sources. In an aspect, a conduction block is produced in a sensory nerve. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain, or an immune or inflammatory response or process. Delivery of blocking stimuli may be controlled in part in response to an input from a user input device.

Method and system for blocking nerve conduction

Methods and related systems for modulating neural activity by cyclical blocking of conduction in peripheral neural structures with electrical blocking stimuli are disclosed. In an aspect, neural activity is blocked cyclically with an electrical blocking stimulus source implanted adjacent a nerve. In an aspect, a conduction block is produced in a sensory nerve. Neural modulation may be used, for example, to modulate an immune or inflammatory response or process.

Methods and related systems for modulating neural activity by cyclical blocking of conduction in peripheral neural structures with ultrasound are disclosed. In an aspect, neural activity is blocked cyclically with an ultrasonic blocking stimulus source positioned adjacent a skin surface in a vicinity of a nerve. In an aspect, a conduction block is produced in a sensory nerve. Neural modulation may be used, for example, to modulate an immune or inflammatory response or process.

Method and system for ultrasonic neural modulation in a limb

Methods and related systems for modulating neural activity by cyclically blocking conduction in peripheral neural structures are disclosed. In an aspect, neural activity is blocked cyclically with a blocking stimulus source positioned adjacent a skin surface in a vicinity of a nerve. Neural modulation may be used, for example, to modulate an immune or inflammatory response or process.

Method and system for modulating neural activity in a limb

Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.

System, devices, and methods including actively-controllable sterilizing excitation delivery implants

Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Implantable systems for delivery of chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

Implant system for chemical modulation of neural activity

A method for enhancing an immune response in a vertebrate subject is described. The method includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject.

Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject

Method and system for reversible chemical modulation of neural activity

Methods, apparatuses, computer program products, devices and systems are described that include accepting one or more blood vessel sleeve dimensions based on blood vessel data from an individual; and making a rapid-prototyped blood vessel sleeve at least partly based on the one or more blood vessel sleeve dimensions.

Methods and systems for making a blood vessel sleeve

An apparatus for enhancing an immune response in a vertebrate subject is described. The apparatus includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject.

Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Systems for transdermal delivery of chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

Growing community of inventors

Webster Groves, MO, United States of America

Joshua L Dowling