Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Hadasit Medical Research Services and Development Ltd.

Joshua Katzhendler

Oren Tirosh

Ron Kohen

Yechezkel Barenholz

Arie Lev Gruzman

Shlomo Sasson

Erol Cerasi

Isaac Ginsburg

Ezequiel Wexselblatt

Ilana Kaspy

Gad Glaser

Roee Vidavski

Hafiz Mawasi

Sigal Ben Yehuda

Yaara Oppenheimer-Shaanan

Yehezkel Barenholz

Rel proteins as a novel therapeutic agent for treating bacterial threats. More specifically, a novel class of compounds of Formula (I) as disclosed herein which possess antibacterial activity and which inhibit RelA, RelSeq or RelSpo synthetic activity or bacterial spore formation. Also, pharmaceutical compositions of such compounds and a method of combating bacteria, or treating bacterial infections, by administering to a subject in need thereof such compounds or pharmaceutical compositions.

Compounds for treating bacterial infections

The present invention relates to pentose and pentose derivatives that are effective at increasing glucose transport in a non-insulin dependent manner, and to uses thereof for a) treating and/or preventing hyperglycemia; b) treating and/or preventing the complications of hyperglycemia; c) treating diabetes; d) increasing the rate of cellular glucose transport; e) increasing the rate of cellular glucose uptake; f) improving the ability of a subject to metabolize glucose; g) treating daily blood glucose fluctuations; h) reducing blood sugar levels; i) reducing the dosage of anti-diabetic medication needed for treatment of diabetes. The present invention further provides novel pentose derivatives having beneficial properties in terms of pharmacokinetics, to pharmaceutical compositions comprising these novel compounds and uses thereof.

Pentose derivatives as anti-hyperglycemic drugs

The invention relates to a compound of formula (I)

Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them

Novel ether-linked phospholipids derivatized with polyethylene glycol at the polar head group are disclosed. Lipid bilayers containing these phospholipids show high oxidative stability. Also disclosed is the use of PEG-derivatized ether-linked lipids in moisturizing and radiation-protective cosmetic compositions.

Radiation-protective phospholipid and method

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Jerusalem, Israel

Joshua Katzhendler