Cold Spring Harbor Laboratory

Hoffmann-La Roche Inc.

Emory University

F. Hoffmann-La Roche Ag

Joshua I Dubnau

Timothy P Tully

Michael Phillip Davis

Ulrich Certa

Jan Mous

Wanhe Li

Lisa Prazak

Michael Davis

The present invention relates to transposon activation and mobilization, particularly in the brain, during normal aging; reporter systems to detect such mobilization, along with cells and transgenic animals containing such systems; methods of monitoring neuronal function during normal aging; methods of determining the risk of age-related neuronal decline and age-related mortality; and the use of transposon inhibitors and apoptosis inhibitors to delay age-related neuronal decline and age-related mortality.

Transposon activation during aging and neuronal decline

The present invention relates to methods of identifying genes involved in memory formation. This is accomplished by performing a gene chip identification of those genes expressed during transcription-dependent memory formation but not during transcription-independent memory formation. A statistical analysis of the gene chip identification output yields a set of genes that are involved in transcription-dependent memory formation.

Gene chip technology for determining memory genes

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Huntington Station, NY, United States of America

Joshua I Dubnau