University of Michigan

Joshua C Doverspike

Mark E Meyerhoff

Elizabeth J Brisbois

Yu Qin

Chuanwu Xi

Maria Kim

Jianfeng Wu

Orsolya I Lautner-Csorba

Shale J Mack

Kamila Katarzyna Konopinska

James Phan

Yang Zhou

A catheter insert device includes a powder composition, and a housing. The powder composition includes a solid phase S-nitrosothiol (RSNO). The housing includes a polymeric wall that is i) permeable to nitric oxide, ii) non-porous, and iii) permeable to water vapor, and an inner lumen defined at least in part by the polymeric wall. The powder composition is completely sealed within the inner lumen of the housing.

Catheter insert devices

A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.

Two-part nitric oxide generating topical compositions

Growing community of inventors

Ann Arbor, MI, United States of America

Joshua C Doverspike