Debut Biotechnology, Inc.

Qualcomm Incorporated

University of California

The Flinders University of South Australia

Joshua Britton

Nicholas Brideau

Tao Wang

Michael Hugh Harrington

Neil Burns

Gregory A Weiss

Andrew Lejman

Marvin Leroy Vis

Julio Zegarra

Thomas J Funk

Erik Holtzapple

Jingyi Li

Ali Morshedi

Larry D Flowers

Colin L Raston

Derek N Punch

James Beckwith

Norman Satoru Himaka

Thanh Duong

Francis Pearce

Dave Henry

Raymond Alexander

Erez Avigdor Falkenstein

Paul Sithideth

Ali Emileh

Derek Punch

Norman Himaka

The invention is directed to methods involved in the production of flavonoids, anthocyanins and other organic compounds. The invention provides cells engineered for the production of flavonoids, anthocyanins and other organic compounds, where the engineered cells include one or more genetic modifications that increase flavonoid production by increasing metabolic flux to flavonoid precursors and/or reducing carbon losses resulting from the production of byproducts.

Flavonoid and anthocyanin bioproduction using microorganism hosts

Geranyl pyrophosphate (GPP) is a key intermediate molecule in the bioproduction of thousands of natural products. Currently, natural products are either cultivated from plants, synthesized via complex chemical synthesis strategies, or through cell-based factories also known as biofoundries. However, in order to replicate the process in a cell free environment, numerous enzymes and cofactors must be utilized making this approach costly and unviable. In order to make this process viable, a new approach was needed that uses fewer enzymes and co-factors. As described herein, the present invention demonstrates that it is possible to create GPP from glycerol through a short and concise biosynthetic pathway outside of the cell.

Cell-free production of geranyl pyrophosphate from glycerol in a cell-free manufacturing system

Glycerol is a byproduct of biodiesel and bioethanol production and its conversion to value-added chemicals is a promising avenue for realization of the biorefinery concept Conversion of glycerol to pyruvate through glycerate yields pyruvate, is a common intermediate of many high-value natural products. The present invention aims at improving the specific activity of a naturally occurring enzyme toward conversion of glycerate to pyruvate (TvDHT). The present invention features compositions of isolated dehydratase enzyme (DHT) polypeptide composition, in particular the DHT polypeptide composition comprising a single point mutation that increases the specific activity of the enzyme as compared to wild type.

Dehydratase variants with improved specific activity for the production of pyruvate from glycerate

A mobile device holder that includes a body having a plurality of cavities. The mobile device holder includes a first assembly, a second assembly, and a third assembly. The first assembly is coupled to the body. The first assembly is configurable to be coupled to different portions of the body. The first assembly includes a first arm configured to be coupled to the body, a first slider coupled to the first arm, where the first slider is configured to move along the first arm, a first cap coupled to the first arm, and a first screw coupled to the first cap, where the first screw is configured to move the first slider along the first arm and towards the body.

Mobile device positioner and configurable mobile device holder

Methods and apparatus are disclosed for near field radio-frequency (RF) testing of devices, particularly user equipment (UEs) capable of millimeter-wave (mmWave) transmissions. An exemplary test apparatus is described that uses a transducer to facilitate near field over-the-air testing of UEs in the mmWave transmission band. The transducer may be an orthomode transducer and may include a dual-polarity port positioned in the reactive near field of an antenna of a device under test (DUT). For UE signal transmission tests, the orthomode transducer splits test signals received from the antenna of the DUT via the dual-polarity port into a pair of single-polarity RF signals. The single-polarity RF signals are separately fed through a pair of waveguide-to-coaxial adaptors into separate coaxial cables, which feed coaxial transmission versions of the single-polarity RF signals to test equipment for analysis. UE signal reception tests are also described that utilize the same or different orthomode transducer.

Near field wireless communication device testing using dual-polarity transducer

There are provided, inter alia, methods for reacting an enzyme and its substrate, methods for purifying a protein and an enzyme reactor and its use thereof.

Methods and compositions for protein purification and enzyme reaction

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Irvine, CA, United States of America

Joshua Britton