Harvard College

University of Washington

Joshua Alan Blodgett

Jon Clardy

E Peter Greenberg

Mohammad Seyedsayamdost

Josephine R Chandler

Breck Duerkop

Patricia Silva Lima

The present inventions are directed to a novel bactobolin analog bactobolin D. The present inventions also are directed to a method of producing a composition comprising at least one bactobolin analog using a bacteria strain comprising a bacterial cell comprising the biosynthetic locus of the bactobolin analog in(bta cluster) or a homolog structure (at least 95% sequence identity) thereof, and further isolation and purification of the bactobolin analog. For example, the bacterial strain can be a wild type bacterial strain such as astrain comprising a bta cluster (e.g.(e.g. E264, Bt4, and TXDOH) and(e.g. K96243, 1106a, and 1106b).

Bactobolin analog and synthesis method thereof

Growing community of inventors

Boston, MA, United States of America

Joshua Alan Blodgett