Varian Medical Systems, Inc.

Varian Medical Systems International Ag

Novaray Medical, Inc.

Varex Imaging Corporation

Siemens Healthineers International Ag

Varian Medical Systems Technologies, Inc.

Collimated Holes, Inc.

Josh Star-Lack

Mingshan Sun

Gary Fredric Virshup

James Edward Clayton

Daniel Shedlock

Adam Shar Wang

Eric Abel

Christel Smith

Michael C Green

John Van Heteren

Hassan Mostafavi

Corey Zankowski

Daniel Morf

John Milan Pavkovich

David T Nisius

David H Humber

Deepak Khuntia

Wolfgang Kaissl

Blake Gaderlund

Camille Noel

Edward J Seppi

Edward Gerald Solomon

Brian Patrick Wilfley

Tobias Funk

Timo K Koponen

Chwen-Yuan Ku

Adam James Wang

Anthony Magliari

Edward G Shapiro

Thomas Anthony Case

Michelle Marie Svatos

Timothy E Guertin

George A Zdasiuk

Jan Timmer

Augustus Percival Lowell

Heinrich Riem

Reynald Vanderstraten

Winston Y Sun

Alexander E Maslowski

Petr Jordan

Richard E Colbeth

Gregory C Andrews

Stanley Mansfield

Timothy R Fox

Arthur Charles Kwun

Erik Chell

Andrew G Jeung

Ross Bernald Hannibal

Pascal Paysan

Stefan J Thieme-Marti

Dieter Marc Seghers

Michelle Richmond

Graham R Faulknor

Dusan Baic

Todd Arlin Wareing

Jan H Timmer

Alyssa J Garver

Marcus Brehm

Viktor Steinlin

Michael Stamm

Matthias Ehrat

Richard Mead

Andre Meyer

Erik William Chell

Samuel Donnald

Kevin Holt

Daniel R Bilsky

Alexander R Brown

Jon Carver

Karla Knott

Roland Suri

Alexander Maslowski

Jan Hein Timmer

David Humber

Ross Hannibal

An imaging system for inspecting multiple objects includes an x-ray source having a beam width greater than or equal to a threshold beam size. The multiple objects is irradiated by the x-ray source in respective controlled inspection positions. A detection mechanism is adapted to acquire respective images of the multiple objects in the respective controlled inspection positions. The detection mechanism includes one or more detectors arranged circumferentially around a central axis. At least one positioning mechanism is adapted to move the multiple objects into and out of the respective controlled inspection positions.

Imaging system with wide x-ray beam and circumferentially arranged detection mechanism

An example method of radiation therapy in a radiation therapy system that includes a gantry with a treatment-delivering X-ray source and an imaging X-ray source mounted thereon is described. The method includes rotating the gantry in a first direction at a first rotational velocity about an open bore and concurrently rotating an annular support structure at a second rotational velocity about the open bore, wherein the second rotational velocity is less than the first rotational velocity. While continuing to rotate the gantry in the first direction about the open bore from a first position to a treatment position, the method also includes generating multiple images of a target volume disposed in the bore using the imaging X-ray source. Upon rotating the gantry to the treatment position, the method includes initiating delivery of a treatment beam to the target volume with the treatment-delivering X-ray source.

Single-pass imaging and radiation treatment delivery via an extended rotation gantry

In a method of making pixelated scintillators, an amorphous scintillator material in a molten state is pressed into a plurality of cavities defined by a plurality of walls of a mesh array. The molten scintillator material in the plurality of cavities is cooled to form a pixelated scintillator array. An x-ray imager including a pixelated scintillator is also described.

Method for fabricating pixelated scintillators

Embodiments include a method, comprising: receiving measured radiation obtained from a radiation detector that received radiation through an object; simulating the measured radiation obtained from the radiation detector that received radiation through the object; generating an offset based on the measured radiation and the simulated measured radiation; estimating scatter radiation based on the offset; and estimating primary radiation based on the estimated scatter radiation.

Estimating background radiation from unknown sources

In various embodiments, a radiation therapy method can include loading a planning image of a target in a human. In addition, the position of the target can be monitored. A computation can be made of an occurrence of substantial alignment between the position of the target and the target of the planning image. Furthermore, after the computing, a beam of radiation is triggered to deliver a dosage to the target in a short period of time (e.g., less than a second).

Triggered treatment systems and methods

Presented systems and methods facilitate efficient and effective generation and delivery of radiation. A radiation generation system can comprise: a particle beam gun, a high energy dissipation anode target (HEDAT); and a liquid anode control component. In some embodiments, the particle beam gun generates an electron beam. The HEDAT includes a solid anode portion (HEDAT-SAP) and a liquid anode portion (HEDAT-LAP) that are configured to receive the electron beam, absorb energy from the electron beam, generate a radiation beam, and dissipate heat. The radiation beam can include photons that can have radiation characteristics (e.g., X-ray wavelength, ionizing capability, etc.). The liquid anode control component can control a liquid anode flow to the HEDAT. The HEDAT-SAP and HEDAT-LAP can cooperatively operate in radiation generation and their configuration can be selected based upon contribution of respective HEDAT-SAP and the HEDAT-LAP characteristics to radiation generation.

Radiation anode target systems and methods

Radiation treatment planning includes determining a number of beams to be directed into a target, determining directions (e.g., gantry angles) for the beams, and determining an energy level for each of the beams. The number of beams, the directions of the beams, and the energy levels are determined such that the beams do not overlap outside the target and the prescribed dose will be delivered across the entire target.

Geometric aspects of radiation therapy planning and treatment

Reconstruction of projection images of a CBCT scan is performed by generating simulated projection data, comparing the simulated projection data to the projection images of the CBCT scan, determining a residual volume based on the comparison, and using the residual volume to determine an accurate reconstructed volume. The reconstructed volume can be used to segment a tumor (and potentially one or more organs) and align the tumor to a planning volume (e.g., from a CT scan) to identify changes, such as shape of the tumor and proximity of the tumor to an organ. These changes can be used to update a radiation therapy procedure, such as by altering a radiation treatment plan and fine-tuning a patient position.

Iterative image reconstruction in image-guided radiation therapy

An imaging device includes: a scintillator layer; and an array of photodiode elements; wherein the scintillator layer is configured to receive radiation that has passed through the array of photodiode elements. An imaging device includes: a scintillator layer having a plurality of scintillator elements configured to convert radiation into photons; and an array of photodiode elements configured to receive photons from the scintillator layer, and generate electrical signals in response to the received photons; wherein at least two of the scintillator elements are separated by an air gap. An imaging device includes: a first scintillator layer having a plurality of scintillator elements arranged in a first plane; and a second scintillator layer having a plurality of scintillator elements arranged in a second plane; wherein the first scintillator layer and the second scintillator layer are arranged next to each other and form a non-zero angle relative to each other.

High DQE imaging device

In a method of making pixelated scintillators, a block of an amorphous scintillator material is divided into plural sections. The plural sections of the block are rejoined with plural first reflective septa to form an assembly. In the assembly, each of the plural first reflective septa separates two adjacent sections of the block. The assembly is then divided into plural sections in a way such that each of the plural sections of the block is divided into plural pixels. The plural sections of the assembly are rejoined with plural second reflective septa. Each of the plural second reflective septa separates two adjacent sections of the assembly, forming an array comprising plural rows and columns of pixels of the amorphous scintillator material. In the array, each pixel is separated from adjacent pixels by a portion of at least one of the plural first reflective septa and at least one of the second reflective septa.

Scintillating glass pixelated imager

An imaging device includes: a first scintillator layer; an array of detector elements, wherein the array of detector elements comprises a first detector element; a second scintillator layer configured to receive radiation after the radiation has passed through the first scintillator layer and the array of detector elements, wherein the array of detector elements is located between the first scintillator layer and the second scintillator layer; a first electrode located closer to the first scintillator than the second scintillator; and a second electrode situated between the second scintillator and the first detector element; the first detector element configured to generate a first electrical signal in response to light from the first scintillator layer, and to generate a second electrical signal in response to light from the second scintillator layer; the second electrode configured to allow the light from the second scintillator layer to reach the first detector element.

Imaging devices

A method of generating an image synthesis process is disclosed, where the image synthesis process improves image quality of degraded volumetric images. In the method, a machine learning process is trained in a supervised learning framework as the image synthesis process. In the supervised learning process, a lower-quality partial-data reconstruction of a target volume is employed as an input object in the supervised learning process and a higher-quality full data reconstruction of the target volume is employed as an expected output. The full data reconstruction is generated based on a first set of projection images of the three-dimensional volume and the partial-data reconstruction is generated based on a second set of projection images of the three-dimensional volume, where the second set of projection images includes projection images that have less image information and/or are of a lower image quality than the first set of projection images.

Adaptive image filtering for volume reconstruction using partial image data

A radiation therapy system delivers radiation treatment over a 360-degree arc and performs a prepended imaging process, in a single pass, via an extended rotation gantry. While rotating the gantry in one direction about a bore of the radiation system, the radiation system generates multiple images of a target volume disposed in the bore using an imaging X-ray source mounted on the gantry. Then, while continuing to rotate the gantry in the same direction, the radiation system delivers a treatment beam to the target volume using a treatment-delivering X-ray source mounted on the gantry, where the treatment beam is delivered from some or all of a 360-degree arc about the bore. Thus, the prepended imaging process and the delivery of radiation are performed in a single pass of the gantry about a target volume, eliminating the need for a return stroke of the gantry for completion.

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Palo Alto, CA, United States of America

Josh Star-Lack